Results 11 to 20 of about 885,675 (316)

Small molecule splicing modifiers with systemic HTT-lowering activity

Nature Communications, 2021
Here the authors describe the discovery of a class of small molecule splicing modifiers which are orally bioavailable, cross the blood-brain barrier, and lower levels of huntingtin in a mouse model of Huntington’s disease (HD).
Anuradha Bhattacharyya, Christopher R. Trotta, Jana Narasimhan, Kari J. Wiedinger, Wencheng Li, Kerstin A. Effenberger, Matthew G. Woll, Minakshi B. Jani, Nicole Risher, Shirley Yeh, Yaofeng Cheng, Nadiya Sydorenko, Young-Choon Moon, Gary M. Karp, Marla Weetall, Amal Dakka, Vijayalakshmi Gabbeta, Nikolai A. Naryshkin, Jason D. Graci, Thomas Tripodi, Amber Southwell, Michael Hayden, Joseph M. Colacino, Stuart W. Peltz   +23 more
doaj   +1 more source

Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

BMC Medicine, 2021
Background Clinically vulnerable individuals have been advised to shield themselves during the COVID-19 epidemic. The objectives of this study were to investigate (1) the rate ratio of severe COVID-19 associated with eligibility for the shielding ...
Paul M. McKeigue, David A. McAllister, David Caldwell, Ciara Gribben, Jen Bishop, Stuart McGurnaghan, Matthew Armstrong, Joke Delvaux, Sam Colville, Sharon Hutchinson, Chris Robertson, Nazir Lone, Jim McMenamin, David Goldberg, Helen M. Colhoun   +14 more
doaj   +1 more source

KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals

Nature Communications, 2021
Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, the authors show that KRas-induced actininteracting protein (KRAP) tethers a small subset of IP3 receptors to actin and licenses them to evoke cytosolic ...
Nagendra Babu Thillaiappan, Holly A. Smith, Peace Atakpa-Adaji, Colin W. Taylor   +3 more
doaj   +1 more source

Association of cerebral venous thrombosis with recent COVID-19 vaccination: case-crossover study using ascertainment through neuroimaging in Scotland

BMC Infectious Diseases, 2021
Background To investigate the association of primary acute cerebral venous thrombosis (CVT) with COVID-19 vaccination through complete ascertainment of all diagnosed CVT in the population of Scotland.
Paul M. McKeigue, Raj Burgul, Jen Bishop, Chris Robertson, Jim McMenamin, Maureen O’Leary, David A. McAllister, Helen M. Colhoun   +7 more
doaj   +1 more source

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

ESC Heart Failure, 2021
Aims Amyloidogenic transthyretin (ATTR) amyloidosis is a fatal disease characterized by progressive cardiomyopathy and/or polyneuropathy. AKCEA‐TTR‐LRx (ION‐682884) is a ligand‐conjugated antisense drug designed for receptor‐mediated uptake by ...
Nicholas J. Viney, Shuling Guo, Li‐Jung Tai, Brenda F. Baker, Mariam Aghajan, Shiangtung W. Jung, Rosie Z. Yu, Sheri Booten, Heather Murray, Todd Machemer, Sebastien Burel, Sue Murray, Gustavo Buchele, Sotirios Tsimikas, Eugene Schneider, Richard S. Geary, Merrill D. Benson, Brett P. Monia   +17 more
doaj   +1 more source

Prediction signals in the cerebellum: Beyond supervised motor learning

eLife, 2020
While classical views of cerebellar learning have suggested that this structure predominantly operates according to an error-based supervised learning rule to refine movements, emerging evidence suggests that the cerebellum may also harness a wider range
Court Hull
doaj   +1 more source

Can the Rwandan Catholic Church Overcome its History of Politicization? A Reply to Philippe Denis [PDF]

Journal for the Study of Religion, 2019
Scholarly interest in Rwanda ranges across all aspects of its history. A substantial body of influential research appeared particularly during the two decades following independence in 1962.
Anthony Court
doaj   +3 more sources

When Special Immigrant Juveniles and Trial Courts Intersect: The Value of Data-Informed Case Management

International Journal for Court Administration, 2017
In recent years, the United States experienced a large influx of unaccompanied alien children (UAC). While state courts do not adjudicate the immigration status of UAC, depending on the circumstances, courts may find themselves involved in the process ...
Danielle Fox, Hisashi Yamagata, Lili Khozeimeh, Esq., Marianne Hendricks, Esq., Madeleine Jones, Esq., Rick Dabbs   +5 more
doaj   +1 more source

Deep Impact On The Mobile Communications Market: A Case Study In Applying The Regulatory Rules To Assess A Proposed Enterprise Combination

SCRIPTed: A Journal of Law, Technology & Society, 2008
The face of communication technology is changing rapidly – fixed-line telephony is in decline, while fourth-generation fully-mobile services are coming to the fore and will be widely available in the near future.
Jongho Kim
doaj   +1 more source

Phosphorylation of the WH2 domain in yeast Las17/WASP regulates G-actin binding and protein function during endocytosis

Scientific Reports, 2021
Actin nucleation is the key rate limiting step in the process of actin polymerization, and tight regulation of this process is critical to ensure actin filaments form only at specific times and at defined regions of the cell.
J. J. Tyler, I. I. Smaczynska-de Rooij, L. Abugharsa, J. S. Palmer, L. P. Hancock, E. G. Allwood, K. R. Ayscough   +6 more
doaj   +1 more source