Results 201 to 210 of about 1,516,828 (318)

Decision letter: Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

, 2021
Ron A. M. Fouchier
openalex   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Inhibition of coronaviral exoribonuclease activity by TRIM-mediated SUMOylation. [PDF]

Proc Natl Acad Sci U S A
Balakrishnan K, Chakraborty S, Chiang C, Stratton CM, Pandey S, Tumanova AA, Olsen SK, Gack MU.   +7 more
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

The Open Reading Frame 7b of the SARS-CoV-2 Disperse Trans-Golgi and Activate the NLRP3 Inflammasome. [PDF]

J Med Virol
García-Villalba J, Hurtado-Navarro L, Angosto-Bazarra D, Baroja-Mazo A, Pelegrin P.   +4 more
europepmc   +1 more source

Peer Review #3 of "Identification and molecular characterization of mutations in nucleocapsid phosphoprotein of SARS-CoV-2 (v0.1)"

, 2021
Gajendra Kumar, Azad Corresp, Gajendra Kumar Azad, Gajendra Kumar Azad, S Ahmed, A Quadeer, M Mckay, I Astuti, Ysrafil, G Azad, D Blanco-Melo, B Nilsson-Payant, W Liu, S Uhl, D Hoagland, R Mller, T Jordan, K Oishi, M Panis, D Sachs, T Wang, R Schwartz, J Lim, R Albrecht, Br, G Chand, A Banerjee, G Azad, G Chand, A Banerjee, G Azad, C Chang, M Hou, C Chang, C Hsiao, T Huang, N Chen, M Zhou, X Dong, J Qu, F Gong, Y Han, Y Qiu, J Wang, Y Liu, Y Wei, J Xia, T Yu, X Zhang, L Zhang, S Chenavas, T Cre in, B Delmas, Rwh Ruigrok, A Slama-Schwok, Y Cong, M Ulasli, H Schepers, M Mauthe, V 'kovski, P Kriegenburg, F Thiel, V De Haan, Cam Reggiori, F, G Crooks, G Hon, J Chandonia, S Brenner, C Franco-Munoz, D Alvarez-Diaz, Laiton- Donato, K Wiesner, M Escandon, P Usme-Ciro, J Franco-Sierra, N Florez-Sanchez, A Gomez-Rangel, S Calderon, Ldr Ramirez, J Baez, E Walteros, D Martinez, Mlo Mercado-Reyes, M, S Gerritz, C Cianci, S Kim, B Pearce, C Deminie, L Discotto, B Mcauliffe, B Minassian, S Shi, S Zhu, W Zhai, A Pendri, G Li, M Poss, S Edavettal   +99 more
openalex   +2 more sources

SARS-CoV-2 roots [PDF]

Nature Ecology & Evolution, 2021
openaire   +2 more sources

Machine Learning‐Driven Variability Analysis of Process Parameters for Semiconductor Manufacturing

Advanced Intelligent Systems, EarlyView.
This research presents a machine learning approach that integrates nonlinear variation decomposition (NLVD) with statistical techniques to quantify the contribution of individual unit processes to performance and variance of figure of merit (FoM) at the LOT level.
Sinyeong Kang, Hyeok Yun, Kyeongrae Cho, Seungjoon Eom, Soomin Kim, Seongsoo Jeong, Rockhyun Baek   +6 more
wiley   +1 more source

SARS-CoV-2 crossreactive B-cells outnumber seasonal coronavirus spike-specific clones at the end of the COVID-19 pandemic. [PDF]

Npj Viruses
Gonzalez-Lopez C, Aguilar-Bretones M, Reinders J, Zhang J, van den Doel P, Bekki B, van Gorp EC, van der Kuy PHM, Haagmans BL, GeurtsVanKessel CH, Koopmans MPG, de Vries RD, van Gils MJ, van Nierop GP.   +13 more
europepmc   +1 more source

COV

Bioelectrochemistry, 2019
openaire   +1 more source