Results 221 to 230 of about 1,516,828 (318)

Pathogenicity of SARS‐CoV‐2 Omicron

Clinical and Translational Medicine, 2022
Hin Chu, Kwok‐Yung Yuen
doaj   +1 more source

Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance. [PDF]

Proc Natl Acad Sci U S A
Tung W, Yuen M, Cai H, Cho H, Lu P, Kliman HJ, Homer RJ, Herrerias A, Salla N, Rivera AR, Liu Y, Pattabiraman K, Iwasaki A.   +12 more
europepmc   +1 more source

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms. [PDF]

Signal Transduct Target Ther
Huang X, Li Y, Deng J, Tan X, Yang S, Liu J, Wu Z, Shi P, Zhou L, Chen Y.   +9 more
europepmc   +1 more source

Author Response: Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

Chung Park, Il‐Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Alexandre Girard, Claudia Cicala, James Arthos, John H. Kehrl   +9 more
openalex   +1 more source

Metadata record for: Structural models of human ACE2 variants with SARS-CoV-2 Spike protein for structure-based drug design

, 2020
Scientific Data Curation Team
openalex   +1 more source

SARS-CoV-2 Infektionen in Deutschland

, 2022
Robert Koch-Institut
openalex   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

The Feasibility of Developing a Universal SARS-CoV-2 Vaccine. [PDF]

Vaccines (Basel)
Asaad M, Mustafa MO, Al-Haneedi Y, Shalaby L, Shams Eldin R, Mohamedahmed Y, Yassine HM, Abdallah AM, Emara MM.   +8 more
europepmc   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source