Results 231 to 240 of about 1,516,828 (318)

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

Angewandte Chemie, EarlyView.
This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Clues to Long COVID Linked to Virulence and Infectivity Found in Shell Proteins. [PDF]

Adv Respir Med
Goh GK, Foster JA, Uversky VN.
europepmc   +1 more source

Analysis of the severe acute respiratory syndrome coronavirus (SARS-CoV-1 and SARS-CoV-2)-dependent transcriptome human lung epithelial cells

, 2020
Emanuel Wyler
openalex   +1 more source

Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures

Annals of Neurology, EarlyView.
Objective Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non‐apneic ventilation or identifying other dysfunctional breathing patterns.
Haley E. Pysick, Rup K. Sainju, Roshni Nair, Deidre N. Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D. Lhatoo, George B. Richerson, Brian K. Gehlbach   +9 more
wiley   +1 more source

A Real‐Time Antifouling Multivalent Aptamer Platform for Wash‐Free Electrochemical Detection of Low‐Abundance Biomarkers in Human Plasma

Angewandte Chemie, EarlyView.
Detection of low‐abundance proteins at the point‐of‐care is key for early detection and real‐time monitoring. The clinical translation of such assays is hindered by biofouling, matrix variability, and signal instability. RT‐MagMAp assay overcomes these challenges and enables precise protein quantification in human plasma using a hierarchical assembly ...
Payel Sen, Survanshu Saxena, Zijie Zhang, Navreen Sandhu, Pranati Das, Jimmy Gu, Todd Hoare, Yingfu Li, Leyla Soleymani   +8 more
wiley   +2 more sources

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

COVID19 Sero-epidemiology and vaccine uptake in two Southern Nigerian clinics. [PDF]

PLOS Glob Public Health
Ugwu CA, Odebode O, Ajayi IO, Olubunmi J, Ifeoluwa B, Adole JA, Akano K, Okolie J, Eromon P, Kio IK, Amadi J, Adebayo PF, Mgbeokwere I, Lawal AO, Adegoke OA, Adeyemi AO, Owhin S, Ayodeji OO, Ahmed A, Henshaw E, Eyitayo ON, Sylvester AA, Omidele A, Emilola K, Funmilayo O, Oyewale Rufus A, Olakunle OO, Oluwaseun O, Matta AM, Bedekar P, Dahmash L, Forconi CS, Moormann AM, Dinglasan RR, Happi CT, Binder RA.   +35 more
europepmc   +1 more source

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

Viral mechanisms, tropism, and clinical relevance regarding the ophthalmic manifestations of SARS-CoV-2 infection. [PDF]

Int J Ophthalmol
González S, Arellano J, Reza-Zaldivar EE, Mena-Munguía S, Minjarez B, Rodríguez-Yáñez Y.   +5 more
europepmc   +1 more source

Using Network Modeling to Understand the Relationship Between SARS-CoV-1 and SARS-CoV-2 [PDF]

, 2020
Bruce, Nicole A, Haywood, Elizabeth Brooke   +1 more
core   +1 more source