Results 291 to 300 of about 1,516,828 (318)

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Disentangling SARS-CoV-2 Sustained Viremia Cases: Evolution, Persistence and Reinfection. [PDF]

Viruses
Alves BM, Moreira FRR, Garrido MM, Carvalho PS, Oliveira ÉM, Sá CC, Arthos J, Cicala C, Viola JPB, Goes LR, Siqueira JD, Soares MA, Brazilian National Cancer Institute COVID-19 Task Force.   +12 more
europepmc   +1 more source

Optimal model‐based design of experiments for parameter precision: Supercritical extraction case

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study investigates the process of chamomile oil extraction from flowers. A parameter‐distributed model consisting of a set of partial differential equations is used to describe the governing mass transfer phenomena in a cylindrical packed bed with solid chamomile particles under supercritical conditions using carbon dioxide as a solvent ...
Oliwer Sliczniuk, Pekka Oinas
wiley   +1 more source

Impact of SARS-CoV-2 Infection on Diabetic Ketoacidosis in Children with Newly Diagnosed Type-1 Diabetes: A Prospective Multicenter Study. [PDF]

Medeni Med J
Hepokur MN, Tutunculer Kokenli F, Emeksiz HC, Onder Camas A, Yasar Kostek H, Kupcu Z, Budak DD, Yildiz M, Isman FK, Bideci A, Cinaz P.   +10 more
europepmc   +1 more source

Development of seropositivity to SARS-CoV-2 over the course of the COVID-19 pandemic in adolescents in a longitudinal cohort study in Cebu, Philippines. [PDF]

PLOS Glob Public Health
Daag JV, Magsakay GL, Rivera SB, Daque MGN, Lobitana I, Lariana MA, Florendo KL, Crisostomo MV, Escoto AC, Premkumar L, Aogo R, Deen J, Katzelnick L, Ylade M.   +13 more
europepmc   +1 more source

Immunization with MVA-based vaccines protects K18-hACE2 mice from SARS-CoV-2 infection-associated inflammatory lesions in brains. [PDF]

Front Immunol
Rosiak M, Clever S, Leitzen E, Beythien G, Michaely LM, Lockow S, Allnoch L, Ciurkiewicz M, Meyer Zu Natrup C, Tuchel T, Tscherne A, Limpinsel L, Sutter G, Volz A, Baumgärtner W, Hülskötter K, Gregor KM.   +16 more
europepmc   +1 more source

A narrative review of SARS-CoV-2 variants and long COVID. [PDF]

J Thorac Dis
Chai X, Qi H, Liu X, Zhou F, Jiang Y, Wu M, Lian S, Wang L, Bao Y.   +8 more
europepmc   +1 more source

SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING. [PDF]

J Gen Virol
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B.   +8 more
europepmc   +1 more source