Results 151 to 160 of about 623,991 (302)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Data Ellipses, HE Plots and Reduced-Rank Displays for Multivariate Linear Models: SAS Software and Examples [PDF]

This paper describes graphical methods for multiple-response data within the framework of the multivariate linear model (MLM), aimed at understanding what is being tested in a multivariate test, and how factor/predictor effects are expressed across ...
Michael Friendly
core  

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

Euclid: The linear-construction covariance and cosmology★

Astronomy & Astrophysics
We study the properties of galaxy cluster two-point correlation function covariance matrices estimated using the linear-construction (LC) method, which is computationally up to 20 times faster than the standard sample-covariance method.
Lindholm V., Sihvola E., Valiviita J., Fumagalli A., Altieri B., Andreon S., Auricchio N., Baccigalupi C., Baldi M., Bardelli S., Battaglia P., Biviano A., Branchini E., Brescia M., Camera S., Capobianco V., Carbone C., Cardone V. F., Carretero J., Casas S., Castellano M., Castignani G., Cavuoti S., Chambers K. C., Cimatti A., Colodro-Conde C., Congedo G., Conversi L., Copin Y., Courbin F., Courtois H. M., Da Silva A., Degaudenzi H., De Lucia G., Dole H., Dubath F., Dupac X., Dusini S., Escoffier S., Farina M., Farinelli R., Ferriol S., Finelli F., Fosalba P., Fotopoulou S., Frailis M., Franceschi E., Fumana M., Galeotta S., George K., Gillis B., Giocoli C., Gracia-Carpio J., Grazian A., Grupp F., Haugan S. V. H., Holmes W., Hormuth F., Hornstrup A., Jahnke K., Jhabvala M., Kermiche S., Kiessling A., Kubik B., Kunz M., Kurki-Suonio H., Le Brun A. M. C., Ligori S., Lilje P. B., Lloro I., Mainetti G., Maiorano E., Mansutti O., Marcin S., Marggraf O., Martinelli M., Martinet N., Marulli F., Massey R. J., Medinaceli E., Mei S., Melchior M., Meneghetti M., Merlin E., Meylan G., Mora A., Moresco M., Moscardini L., Nakajima R., Neissner C., Niemi S.-M., Padilla C., Paltani S., Pasian F., Pedersen K., Pettorino V., Pires S., Polenta G., Poncet M., Popa L. A., Raison F., Renzi A., Rhodes J., Riccio G., Romelli E., Roncarelli M., Rosset C., Saglia R., Sakr Z., Sánchez A. G., Sapone D., Schneider P., Schrabback T., Secroun A., Seidel G., Simon P., Sirignano C., Sirri G., Stanco L., Tallada-Crespí P., Taylor A. N., Tereno I., Toft S., Toledo-Moreo R., Torradeflot F., Tutusaus I., Vassallo T., Verdoes Kleijn G., Wang Y., Weller J., Zamorani G., Zucca E., Castro T., Martín-Fleitas J., Monaco P., Pezzotta A., Scottez V., Sereno M., Viel M., Sciotti D.   +139 more
doaj   +1 more source

Soil pH Amelioration Synergizes Carbon Accrual with Yield Gains Under Organic Substitution

Advanced Science, EarlyView.
Soil pH shifts towards neutrality in both acidic and alkaline soils under organic substitution. A global synthesis links pH amelioration to soil organic carbon accrual through enhanced microbial biomass after accounting for added organic carbon and its interaction with pH. This pH amelioration‐shared soil organic carbon accrual accounts for 5.1–8.6% of
Xunzhuo Dong, Yanzhong Yao, Bingbing Han, Yunyao Zhong, Benyi Li, Mengfei Li, Yunchao Dai, Zhaolei Li   +7 more
wiley   +1 more source

Improved Test for High-Dimensional Mean Vectors and Covariance Matrices Using Random Projection

Mathematics
This paper proposes an improved random projection-based method for testing high-dimensional two-sample mean vectors and covariance matrices. For mean testing, the proposed approach incorporates training data to guide the construction of projection ...
Tung-Lung Wu
doaj   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Improving Covariance Matrices Derived from Tiny Training Datasets for the Classification of Event-Related Potentials with Linear Discriminant Analysis. [PDF]

Neuroinformatics, 2021
Sosulski J, Kemmer JP, Tangermann M.
europepmc   +1 more source

Hardware Acceleration of Stochastic Neural Networks Enabled by Bit‐Cell Level Co‐Design of Magnetic Tunnel Junctions

Advanced Science, EarlyView.
An MTJ‐based probabilistic processing‐in‐memory architecture unites nonvolatile storage, local entropy generation, and stochastic computation within each memory cell. Stored multi‐bit weights are converted directly into programmable stochastic bitstreams, enabling neural‐network inference, adaptive Ising optimization, and uncertainty‐aware Bayesian ...
Qiuyuan Wang, Dooyong Koh, Brooke McGoldrick, Tudor Mocioi, Yabin Fan, Marc Baldo, Luqiao Liu   +6 more
wiley   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source