Results 141 to 150 of about 3,211,049 (333)

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

A New Statistical Method for Determining the Clutter Covariance Matrix in Spatial-Temporal Adaptive Processing of a Radar Signal. [PDF]

Sensors (Basel), 2023
Kawalec A, Ślesicka A, Ślesicki B.
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Cross-Validated Loss-Based Covariance Matrix Estimator Selection in High Dimensions. [PDF]

J Comput Graph Stat, 2023
Boileau P, Hejazi NS, van der Laan MJ, Dudoit S.   +3 more
europepmc   +1 more source

Improved estimation of the covariance matrix of stock returns with an application to portofolio selection [PDF]

This paper proposes to estimate the covariance matrix of stock returns by an optimally weighted average of two existing estimators: the sample covariance matrix and single-index covariance matrix.
Michael Wolf, Olivier Ledoit
core  

Design and Optimization of Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces Based on Conditional Multi‐Task Deep Learning

Advanced Science, EarlyView.
A conditional multi‐task deep learning framework is developed for designing and optimizing Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces (FHPEMs). This framework achieves joint spectro‐polarimetric learning and unified forward–inverse design.
Chenjie Gong, Haodong Shi, Qi Wang, Yingchao Li, Hongyu Sun, Jiayu Wang, Guanlin Li, Jian Zhang, Qiang Fu, Huilin Jiang   +9 more
wiley   +1 more source

Robust Covariance Matrix Estimation for High-Dimensional Compositional Data with Application to Sales Data Analysis. [PDF]

J Bus Econ Stat, 2023
Li D, Srinivasan A, Chen Q, Xue L.
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

A Computationally Efficient MUSIC Algorithm with an Enhanced DOA Estimation Performance for a Crossed-Dipole Array

Sensors
In this article, an improved real-valued dimension-reduction MUSIC (IRDR-MUSIC) algorithm is proposed for a crossed-dipole array. Initially, conjugate symmetry of the spatial component in the manifold vector is derived such that two real-valued matrices ...
Hao Nan, Xiaofeng Ma, Yubing Han, Weixing Sheng   +3 more
doaj   +1 more source

Improved Speech Spatial Covariance Matrix Estimation for Online Multi-Microphone Speech Enhancement. [PDF]

Sensors (Basel), 2022
Kim M, Cheong S, Song H, Shin JW.
europepmc   +1 more source