Results 291 to 300 of about 4,500,411 (350)

LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim, Janghan Lee, Seo‐Yeon Kim, Jihoon Kim, Moo Sun Hong   +4 more
wiley   +1 more source

Machine Learning‐Based PAT Tool for Real‐Time Residual Moisture Monitoring in Lyophilized Biopharmaceuticals Using NIR Spectroscopy

Biotechnology and Bioengineering, EarlyView.
ABSTRACT There is a growing demand in the pharmaceutical industry to optimize analytical methodologies, reducing time and resource consumption while ensuring rapid process development and cost‐efficient manufacturing. Indeed, Food and Drug Administration (FDA) introduced the Process Analytical Technology (PAT) as an initiative enabling manufacturers to
Samuele Fiorenza, Mariapia D'Urso, Ambra Massei, Nunzia Falco, Davide Fissore, Enza Torino   +5 more
wiley   +1 more source

Quantitative Partitioning of Photoautotrophic and Photoheterotrophic Contributions During Mixotrophic Growth of Scenedesmus obliquus

Biotechnology and Bioengineering, EarlyView.
Carbon and oxygen fluxes during photoautotrophic, photoheterotrophic and mixotrophic growth of Scenedesmus obliquus. ABSTRACT Mixotrophic growth of microalgae involves the simultaneous assimilation of inorganic and organic carbon sources, but the quantitative contributions of photoautotrophic and photoheterotrophic metabolisms remain poorly resolved ...
Solène Jahan, Thibault Combroux, Samy Kemel, Hélène Marec, Mariana Titica, Howard Fallowfield, Jérémy Pruvost, Guillaume Cogne   +7 more
wiley   +1 more source

Dynamics of biotic resistance to plant invasions

Biological Reviews, EarlyView.
ABSTRACT Biotic resistance, the reduction in invasion success caused by native communities, plays an important role in the long‐term dynamics of biological invasions. A large body of empirical research on biotic resistance has accumulated since the last comprehensive review on the subject 20 years ago, enabling us to achieve a refined understanding of ...
Christine S. Sheppard, Joshua I. Brian, Wayne Dawson, Petr Dostál, Franz Essl, Michal Gruntman, Tina Heger, Mark van Kleunen, Mialy Razanajatovo, Lena C. Reimann, Frank M. Schurr, Montserrat Vilà, Florencia A. Yannelli, Marina Golivets   +13 more
wiley   +1 more source

Evidence for adaptive explanations of semelparity in animals

Biological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher, Roberto Salguero‐Gómez   +1 more
wiley   +1 more source

A global meta‐analysis of non‐lethal mammal browsing control in forests

Biological Reviews, EarlyView.
ABSTRACT Increasing resource demand, desire to sequester atmospheric carbon, and conservation goals are driving a need for forests to be managed more effectively in the face of numerous challenges. One such challenge is damage perpetrated by browsing mammals, which can cause substantial financial and ecological impacts.
James B.H. Grimsdale, Daniel W.A. Noble, Geoffrey M. While, Dean Williams, Julianne O'Reilly‐Wapstra   +4 more
wiley   +1 more source

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Large-scale Sparse Inverse Covariance Matrix Estimation

SIAM Journal of Scientific Computing, 2019
The estimation of large sparse inverse covariance matrices is a ubiquitous statistical problem in many application areas such as mathematical finance, geology, health, and many others.
Olaf Schenk, Matthias Bollhöfer, Aryan Eftekhari   +2 more
exaly   +2 more sources

DoA Estimation Using Neural Network-Based Covariance Matrix Reconstruction

IEEE Signal Processing Letters, 2021
In this paper, we discuss a new approach to direction of arrival estimation for systems with subarray sampling. We propose to estimate the covariance matrix of the full array from the sample covariance matrices of the subarrays using a neural network ...
Andreas Barthelme, W. Utschick
semanticscholar   +1 more source

Improved estimation of the covariance matrix of stock returns with an application to portfolio selection

Journal of Empirical Finance, 2003
Olivier Ledoit, Michael Wolf
exaly   +2 more sources

Augmented Covariance Matrix Reconstruction for DOA Estimation Using Difference Coarray

IEEE Transactions on Signal Processing, 2021
As is well known, nonuniform linear arrays have significant advantages in array aperture and degrees of freedom over uniform linear arrays. Using their difference coarrays, subspace-based approaches can be utilized to perform underdetermined and high ...
Zhi Zheng, Yixiao Huang, Wen-Qin Wang, Hing C. So   +3 more
semanticscholar   +1 more source