Results 121 to 130 of about 3,655 (256)
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions
Biotechnology and Bioengineering, EarlyView.ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu +2 more
wiley +1 more source
LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models
Biotechnology and Bioengineering, EarlyView.ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim +4 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT There is a growing demand in the pharmaceutical industry to optimize analytical methodologies, reducing time and resource consumption while ensuring rapid process development and cost‐efficient manufacturing. Indeed, Food and Drug Administration (FDA) introduced the Process Analytical Technology (PAT) as an initiative enabling manufacturers to
Samuele Fiorenza +5 more
wiley +1 more source
High-Precision Laser Time-Frequency Synchronization in Space Based on an Improved Kalman Filtering Method. [PDF]
Sensors (Basel)Sun B, Wang X, Sun Z, Zheng F.
europepmc +1 more source
Advances in causal discovery methods for ecological time series
Biological Reviews, EarlyView.ABSTRACT Recent advances in data collection technologies (e.g. automated sensor networks, satellite remote sensing, and high‐throughput sequencing) have greatly expanded the availability of ecological time series, enabling new opportunities for causal analyses in dynamic ecosystems.
Kenta Suzuki +6 more
wiley +1 more source
An Adaptive Detection Algorithm for Non-Uniform Sea Clutter Background Targets Based on Iterative Weighting and Sample Purification. [PDF]
Sensors (Basel)Su H, Zhang L, Zhao C, Li K.
europepmc +1 more source
Dynamics of biotic resistance to plant invasions
Biological Reviews, EarlyView.ABSTRACT Biotic resistance, the reduction in invasion success caused by native communities, plays an important role in the long‐term dynamics of biological invasions. A large body of empirical research on biotic resistance has accumulated since the last comprehensive review on the subject 20 years ago, enabling us to achieve a refined understanding of ...
Christine S. Sheppard +13 more
wiley +1 more source
Information-Theoretic Dual Adaptive Control Revisited: Multivariable Extension with Applications to Fault-Tolerant Control. [PDF]
Entropy (Basel)Yamé JJ.
europepmc +1 more source
Evidence for adaptive explanations of semelparity in animals
Biological Reviews, EarlyView.ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher +1 more
wiley +1 more source