Results 61 to 70 of about 166,649 (278)

Exploring treatment by covariate interactions using subgroup analysis and meta-regression in cochrane reviews: a review of recent practice. [PDF]

open access: yesPLoS ONE, 2015
Treatment by covariate interactions can be explored in reviews using interaction analyses (e.g., subgroup analysis). Such analyses can provide information on how the covariate modifies the treatment effect and is an important methodological approach for ...
Sarah Donegan   +4 more
doaj   +1 more source

Effects of data preprocessing on results of the epidemiological analysis of coronary heart disease and behaviour-related risk factors

open access: yesAnnals of Medicine, 2021
Background We carried out this study to demonstrate the effects of outcome sensitivity, participant exclusions, and covariate manipulations on results of the epidemiological analysis of coronary heart disease (CHD) and its behaviour-related risk factors ...
Ari Voutilainen   +3 more
doaj   +1 more source

Covariate order tests for covariate effect.

open access: yesLifetime data analysis, 2002
A new approach for constructing tests for association between a random right censored life time variable and a covariate is proposed. The basic idea is to first arrange the observations in increasing order of the covariate and then base the test on a certain point process defined by the observation times.
openaire   +4 more sources

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

open access: yesMolecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina   +17 more
wiley   +1 more source

Covariance in plasticity [PDF]

open access: yesProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2013
Covariance is imposed to the second law of thermodynamics and consequences are shown for elastic-perfectly plastic bodies. In this setting, pointwise balances of standard and configurational actions, constitutive restrictions on the first Piola–Kirchhoff stress and the Eshelby one, and the structure of the dissipation are all derived from a unique ...
openaire   +4 more sources

VISUALIZATION OF COVARIANCE AND CROSS-COVARIANCE FIELDS [PDF]

open access: yesInternational Journal for Uncertainty Quantification, 2013
We present a numerical technique to visualize covariance and cross-covariance fields of a stochastic simulation. The method is local in the sense that it demonstrates the covariance structure of the solution at a point with its neighboring locations. When coupled with an efficient stochastic simulation solver, our framework allows one to effectively ...
Dongbin Xiu, Mike Kirby, Chao Yang
openaire   +2 more sources

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

A Conditional Randomization Test to Account for Covariate Imbalance in Randomized Experiments

open access: yesJournal of Causal Inference, 2016
We consider the conditional randomization test as a way to account for covariate imbalance in randomized experiments. The test accounts for covariate imbalance by comparing the observed test statistic to the null distribution of the test statistic ...
Hennessy Jonathan   +4 more
doaj   +1 more source

Nonparametric goodness‐of‐fit testing for parametric covariate models in pharmacometric analyses

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2021
The characterization of covariate effects on model parameters is a crucial step during pharmacokinetic/pharmacodynamic analyses. Although covariate selection criteria have been studied extensively, the choice of the functional relationship between ...
Niklas Hartung   +3 more
doaj   +1 more source

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