Results 41 to 50 of about 263,263 (320)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
The Five Main Themes of the Old Testament [PDF]
, 2015 Definition and history of the Old Testament themes of covenant, kingship, grace, sacrifice, and ...
Mumme, Laura E.
core +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
St Andrews Encyclopaedia of Theology, 2023 Israel is a prominent topic in the Jewish and Christian scriptures, though it was not as prominent in Christian theological reflection until the aftermath of the Holocaust.
John Goldingay
doaj
Security and Defence Quarterly, 2016 Modern political thinkers have ushered in the theoretical concepts of modern alliances and collective security/defense. Before these political theories were turned into modern organizations, many radical changes had to take place in how international ...
Milton Paul Davis
doaj +1 more source
A Few Random Thoughts About Socio-Economic Rights in the United States in Light of the 2008 Financial Meltdown [PDF]
, 2009 Socio-economic rights, first articulated in the Universal Declaration of Human Rights (UDHR) sixty years ago, are regaining currency. Legal practitioners around the world, emboldened by emerging constitutional democracies in Eastern Europe and South ...
Banks, Taunya Lovell
core +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
DE CALVIN À ALTHUSIUS L’importance du modèle ecclésiologique réformé pour la pensée fédérale
Koers : Bulletin for Christian Scholarship, 2017 In this article, the relationship between Johannes Althusius’ federal views of civil government – as expressed in his Politica methodice digesta – and John Calvin’s conception of the role and function of public authorities, is examined in the light of ...
Eric Kayayan
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