Results 61 to 70 of about 810,095 (233)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
ReligionsHow are Pentecostal theologies, doctrines, and practices deployed in navigating urban spaces? This paper examines how covering—a concept and practice deployed in some Pentecostal and charismatic churches—is deployed and negotiated in navigating life in ...
Admire Thonje
doaj +1 more source
Mathematical Analysis of Malfunctions Caused by Seepage Water to the Republic Radioactive Waste Dump in Mochovce [PDF]
Acta Montanistica Slovaca, 2007 The storage of radioactive waste and the problem of assuring the low and medium radioactive waste is an actual interdisciplinary problem. An important factor influencing on a complex approach to solving these problems is also a creation of suitable ...
Jozef Kuzma, Luboš Hruštinec
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Engenharia Agrícola, 2005 O presente trabalho teve o objetivo de avaliar o ambiente térmico no interior de modelos físicos de galpões avícolas construídos em escala reduzida (1:10). O conforto térmico foi avaliado por meio do Índice de Temperatura do Globo Negro e Umidade (ITGU),
Pedro A. dos Santos +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Un/covering: Making Disability Identity Legible
Disability Studies Quarterly, 2017 This article examines one aspect of disability identity among people with non-apparent or "invisible" disabilities: the decision to emphasize, remind others about, or openly acknowledge impairment in social settings.
Heather Dawn Evans
doaj +1 more source