Results 91 to 100 of about 2,358,953 (205)

3D‐AJP: Fabrication of Advanced Microarchitected Multimaterial Ceramic Structures via Binder‐Free and Auxiliary‐Free Aerosol Jet 3D Nanoprinting

Advanced Science, EarlyView.
A new paradigm in manufacturing microarchitected multimaterial 3D ceramics is demonstrated. Precise ceramic microlattices, spirals, and microwalls with ultralow shrinkage are achieved via droplet‐based printing without any auxiliary support. ZnO ceramic microwalls via this technique are demonstrated as electrodes for breast cancer biomarker detection ...
Chunshan Hu, Sanjida Jahan, Bin Yuan, Rahul Panat   +3 more
wiley   +1 more source

Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis

Advanced Science, EarlyView.
The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu, Kristen D. Popowski, Christina M. Eckhardt, Weihang Zhang, Junlang Li, Yujia Jing, Dylan Silkstone, Elizabeth Belcher, Megan Cislo, Shiqi Hu, Halle Lutz, Asma Ghodsi, Mengrui Liu, Phuong‐Uyen C. Dinh, Ke Cheng   +14 more
wiley   +1 more source

The Antiviral Efficacy and Safety of Azvudine in Hospitalized SARS‐CoV‐2 Infected Patients with Liver Diseases Based on a Multicenter, Retrospective Cohort Study

Advanced Science, EarlyView.
Azvudine shows benefits in reducing all‐cause mortality in hospitalized SARS‐CoV‐2 infected patients and liver diseases. COVID‐19 patients with kidney disease and without autoimmune diseases show a preference for azvudine. Azvudine may be a promising antiviral agent for treating COVID‐19 concomitant with liver diseases.
Junyi Sun, Mengzhao Yang, Guanyue Su, Ling Wang, Xiaobo Hu, Yongjian Zhou, Guangying Cui, Guowu Qian, Yiqiang Yuan, Xinjun Hu, Silin Li, Hong Luo, Shixi Zhang, Guangming Li, Donghua Zhang, Guotao Li, Ming Cheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation

Advanced Science, EarlyView.
A ROS‐driven in situ oxygen supply nanoventilator based on enzyme nanocapsule can convert ROS into O2 through enzyme cascade reaction between SOD and CAT to relieve lung hypoxia, and kill MRSA by releasing vancomycin, which effectively reduces HIF‐1α expression and balances pro‐inflammatory/anti‐inflammatory macrophages ratio, thereby reducing the ...
Zheng Luo, Qi Wang, Xiaotong Fan, Xue Qi Koh, Xian Jun Loh, Caisheng Wu, Zibiao Li, Yun‐Long Wu   +7 more
wiley   +1 more source

UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation

Advanced Science, EarlyView.
This article studies the role of UFMylation in NLRP3 inflammasome activation. It reveals that UFMylation, mediated by the E3 Ufm1‐ligase 1 (Ufl1), maintains NLRP3 stability by preventing its ubiquitination and subsequent autophagic degradation.
Jiongjie Jing, Fan Yang, Ke Wang, Mintian Cui, Ni Kong, Shixi Wang, Xiaoyue Qiao, Fanyu Kong, Dongyang Zhao, Jinlu Ji, Lunxian Tang, Jiaxin Gao, Yu‐Sheng Cong, Deqiang Ding, Kun Chen   +14 more
wiley   +1 more source

T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu, Wei Zhang, Zhongshuai You, Guangyao Li, Chuqi Wang, Changhai Lei, Jian Zhao, Jin Hou, Shi Hu   +8 more
wiley   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Development and evaluation of regression tree models for predicting in-hospital mortality of a national registry of COVID-19 patients over six pandemic surges [PDF]

BACKGROUND: Objective prognostic information is essential for good clinical decision making. In case of unknown diseases, scarcity of evidence and limited tacit knowledge prevent obtaining this information. Prediction models can be useful, but need to be
Dutch COVID-19 Research Consortium
core  

Polyplex Nanomicelle‐Mediated Pgc‐1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice

Advanced Science, EarlyView.
This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du, Hideyuki Nakanishi, Takashi Yamada, Yooksil Sin, Katsura Minegishi, Norio Motohashi, Yoshitsugu Aoki, Keiji Itaka   +7 more
wiley   +1 more source

Pan‐Variant SARS‐CoV‐2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes

Advanced Science, EarlyView.
An integrative approach identifies conserved B‐cell and T‐cell epitopes within SARS‐CoV‐2 proteins, redirecting immune responses from variable to conserved regions. These epitopes elicit robust humoral and cellular immunity, neutralizing diverse viral variants. Promiscuous T‐cell epitopes demonstrate cross‐species efficacy, highlighting their potential
Masaud Shah, Sung Ung Moon, Ji‐Yon Shin, Ji‐Hye Choi, Doyoon Kim, Hyun Goo Woo   +5 more
wiley   +1 more source