Results 101 to 110 of about 4,426,223 (261)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Thrombotic and haemorrhagic complications in critically ill patients with COVID-19: a multicentre observational study [PDF]

, 2020
Akshay Shah, Killian Donovan, Anna McHugh, Manish Pandey, Louise Aaron, Charlotte Bradbury, Simon Stanworth, Raza Alikhan, Stephen Von Kier, Keith Maher, Nicola Curry, Susan Shapiro, Matthew Rowland, Matt Thomas, R. Preston Mason, M.R. Holland, Tom Holmes, Michael R. Ware, Stefan Gurney, Stuart McKechnie   +19 more
openalex   +1 more source

The COVID-19 vaccination

Medicina Clínica (English Edition), 2021
Casas, Irma, Mena, Guillermo
openaire   +4 more sources

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

, 2022
Iain Stewart, Joseph Jacob, Peter M. George, Philip L. Molyneaux, Joanna C. Porter, Richard J. Allen, Shahab Aslani, J. Kenneth Baillie, Shaney Barratt, Paul Beirne, Stephen Bianchi, John Blaikley, James D. Chalmers, Rachel C. Chambers, Nazia Chadhuri, Christopher M. Coleman, Guilhem Collier, Emma Denneny, Annemarie B Docherty, Omer Elneima, Rachael A Evans, Laura Fabbri, Michael Gibbons, Fergus Gleeson, Bibek Gooptu, Neil Greening, Beatriz Guillén‐Guío, Ian P. Hall, Neil A. Hanley, Victoria Harris, Ewen M Harrison, Melissa Heightman, Toby Hillman, Alex Horsley, Linzy Houchen‐Wolloff, Ian Jarrold, Simon R. Johnson, Mark G. Jones, Fasihul Khan, Rod Lawson, Olivia C. Leavy, Nazir Lone, Michael Marks, Hamish McAuley, Puja Mehta, Dhruv Parekh, Karen Piper Hanley, Manuela Platé, John E. Pearl, Krisnah Poinasamy, Jennifer K Quint, Betty Raman, Matthew Richardson, Pilar Rivera‐Ortega, Laura Saunders, Ruth Saunders, Malcolm G. Semple, Marco Sereno, Aarti Shikotra, A. John Simpson, Amisha Singapuri, D Smith, Mark Spears, Lisa Spencer, Stefan Stanel, David Thickett, A. A. Roger Thompson, Mathew Thorpe, Simon Walsh, S Walker, Nicholas Weatherley, Mark C. Willingham, Jim M. Wild, Dan Wootton, Christopher E. Brightling, Ling‐Pei Ho, Louise V. Wain, Gísli Jenkins   +77 more
openalex   +1 more source

Approved and marketed nanoparticles for disease targeting and applications in COVID-19 [PDF]

, 2021
Ahmed A. H. Abdellatif, Abdullah Fahad Alsowinea   +1 more
openalex   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Amantadine for COVID‐19 [PDF]

The Journal of Clinical Pharmacology, 2020
Grieb, Paweł, Świątkiewicz, Maciej, Prus, Katarzyna, Rejdak, Konrad   +3 more
openaire   +3 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review

, 2021
Hadis Fathizadeh, Saman Afshar, Mahmood Reza Masoudi, Pourya Gholizadeh, Mohammad Asgharzadeh, Khudaverdi Ganbarov, Şükran Köse, Mehdi Yousefi, Hossein Samadi Kafil   +8 more
openalex   +2 more sources