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ADME and Pharmacokinetic Properties of Remdesivir: Its Drug Interaction Potential [PDF]

open access: yesPharmaceuticals, 2021
On 11 March 2020, the World Health Organization (WHO) classified the Coronavirus Disease 2019 (COVID-19) as a global pandemic, which tested healthcare systems, administrations, and treatment ingenuity across the world.
Subrata Deb   +3 more
doaj   +3 more sources

Repurposed pharmacological agents for the potential treatment of COVID-19: a literature review [PDF]

open access: yesRespiratory Research, 2021
Background The COVID-19 pandemic has affected the world extraordinarily. This disease has a potential to cause a significantly severe course of disease leading to respiratory complications, multiple organ failure and possibly death.
Alina Kröker, Madara Tirzīte
doaj   +2 more sources

Current Status of Baricitinib as a Repurposed Therapy for COVID-19 [PDF]

open access: yesPharmaceuticals, 2021
The emergence of the COVID-19 pandemic has mandated the instant (re)search for potential drug candidates. In response to the unprecedented situation, it was recognized early that repurposing of available drugs in the market could timely save lives, by ...
Maha Saber-Ayad   +6 more
doaj   +3 more sources

Analysis of the efficacy of Chinese medicine in the treatment of covid-19 and the study of medication pattern [PDF]

open access: yesITM Web of Conferences, 2022
In order to explore the efficacy and medication pattern of Chinese medicine in the treatment of COVID-19, we conducted statistics on the medication use of Chinese medicine based on some clinical data of novel coronavirus pneumonia (COVID-19) and related ...
Cong Xiaoqing, Ren Xiaoqiang
doaj   +1 more source

Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics

open access: yesPharmaceutics, 2021
Since coronavirus disease 2019 (COVID-19) is a serious new worldwide public health crisis with significant morbidity and mortality, effective therapeutic treatments are urgently needed.
Dan-Yang Liu   +7 more
doaj   +1 more source

Key Considerations for Phase 2 or 3 Clinical Study Design of Anti-Inflammatory Agent for COVID-19 Treatment

open access: yesFrontiers in Pharmacology, 2022
Purpose: Current understanding of COVID-19 disease progression suggests a major role for the “cytokine storm” as an important contributor to COVID-19 mortality.
Yewon Park   +4 more
doaj   +1 more source

Pharmacogenetics Approach for the Improvement of COVID-19 Treatment

open access: yesViruses, 2021
The treatment of coronavirus disease 2019 (COVID-19) has been a challenge. The efficacy of several drugs has been evaluated and variability in drug response has been observed.
Ingrid Fricke-Galindo   +1 more
doaj   +1 more source

Drug‐drug interactions with candidate medications used for COVID‐19 treatment: An overview

open access: yesPharmacology Research & Perspectives, 2021
Drug‐drug interaction (DDI) is a common clinical problem that has occurred as a result of the concomitant use of multiple drugs. DDI may occur in patients under treatment with medications used for coronavirus disease 2019 (COVID‐19; i.e., chloroquine ...
Haleh Rezaee   +5 more
doaj   +1 more source

Clinical experience of treatment of immunocompromised individuals with persistent SARS-CoV-2 infection based on drug resistance mutations determined by genomic analysis: a descriptive study

open access: yesBMC Infectious Diseases, 2023
Background The efficacy of antiviral drugs that neutralize antibody drugs and fight against SARS-COV-2 is reported to be attenuated by genetic mutations of the virus in vitro.
Haruka Shimazu   +9 more
doaj   +1 more source

Evaluation of potential drug-drug interactions and polypharmacy in hospitalized COVID-19 patients [PDF]

open access: yes, 2022
Background: Drugs that are used in COVID-19 infection, may interact with each other, as well as with the drugs for comorbidities, used concomitantly with COVID-19 treatment.
Erarslan, Sertaş   +3 more
core   +2 more sources

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