Results 161 to 170 of about 5,901 (234)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Impact, use, and implications of artificial intelligence in public health decision making by elected officials: a scoping review. [PDF]

Front Public Health
Campbell EA, Goodtree H, Gillani S, Oyefolu O, Kelly A, Rivers C, Watson C.   +6 more
europepmc   +1 more source

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

Influence of the COVID-19 pandemic on drug and healthcare utilisation among First Nations with diabetes in Alberta, Canada: a retrospective cohort study. [PDF]

BMJ Open
Weaver O, Sarin C, Samanani S, Crowshoe L, Ye M, Eurich DT.   +5 more
europepmc   +1 more source

Hidden Markov graphical models with state‐dependent generalized hyperbolic distributions

Canadian Journal of Statistics, EarlyView.
Abstract In this article, we develop a novel hidden Markov graphical model to investigate time‐varying interconnectedness between different financial markets. To identify conditional correlation structures under varying market conditions and accommodate shape features embedded in financial time series, we rely upon the generalized hyperbolic family of ...
Beatrice Foroni, Luca Merlo, Lea Petrella   +2 more
wiley   +1 more source

Self-administered digital vaccination decision-aids in primary care: A pilot study of COVID-19 vaccination in Atlanta, GA. [PDF]

Digit Health
White J, Shah T, Wall E, Patel SA, Wu K, Shi Y, Zhang Y, Dong Z, Kulshreshtha A.   +8 more
europepmc   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, EarlyView.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

The power of powerful others: health locus of control and vaccination behavior in rural Namibian pastoralists. [PDF]

BMC Glob Public Health
Prall S, Scelza B, Lopes A.
europepmc   +1 more source

Sustainable Development, Environmental Certification and the Financial Performance of the Road Passenger Transportation Sector

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Within the framework of sustainable development and environmental policy, environmental certification is regarded as a mechanism through which road passenger transport companies (RPTCs) could mitigate their adverse environmental impacts and attain competitive advantages that may enhance their financial performance.
Jose Antonio Cavero‐Rubio, Monica Gonzalez‐Morales   +1 more
wiley   +1 more source

Herpes Zoster (HZ) Over the Past 10 Years: A Systematic Review on Trends, Triggers, and Post-COVID-19 Impact. [PDF]

Cureus
Dameche K, Shams S, AlMesallam MS.
europepmc   +1 more source