Results 251 to 260 of about 280,649 (271)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Long-term trends in reporting of cardiac adverse drug reactions to COVID-19 vaccines - an exploratory analysis of the EudraVigilance database. [PDF]

BMC Infect Dis
Nazar W, Romantowski J, Nazar G, Niedoszytko M, Daniłowicz-Szymanowicz L.   +4 more
europepmc   +1 more source

Africa's Leadership in Global Development Debates: Contribution of the Common African Position to the Post‐2015 Development Agenda and Sustainable Development Goals

Sustainable Development, EarlyView.
ABSTRACT The adoption of the Common African Position (CAP) by the African Union in 2014 marked a transformative shift in Africa's engagement with global development, shaping the post‐2015 development agenda and sustainable development goals (SDGs). Despite its significance, the CAP's contributions remain underacknowledged in mainstream narratives. This
Hafte Gebreselassie Gebrihet, Fabio Andrés Díaz Pabón, Azza Mustafa Babikir Ahmed   +2 more
wiley   +1 more source

Lingering Hesitancy: Persistent Uncertainty About the COVID-19 Vaccines Among Previously Vaccinated Individuals. [PDF]

AJPM Focus
Kazungu FK, Almukhtar S, Stiehl E, Khare MM, Hershow RC, Basu S, McWhirter N, Kim SJ.   +7 more
europepmc   +1 more source

Balancing allocative and dynamic efficiency with redundant R&D allocation: The role of organizational proximity and centralization

Strategic Management Journal, EarlyView.
Abstract Research Summary Resource‐based‐view scholars have mainly examined two resource allocation approaches for competitive advantage in multiunit firms: resource sharing and resource redeployment. These approaches emphasize allocative efficiency—the optimal allocation of resources to maximize their current value. In technology‐intensive industries,
Vivek Tandon, Anand Nandkumar, Ronak Mogra, Kannan Srikanth   +3 more
wiley   +1 more source

Safety of JN.1-Updated mRNA COVID-19 Vaccines.

JAMA Netw Open
Andersson NW, Thiesson EM, Hviid A.
europepmc   +1 more source

Active vaccine safety surveillance: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya. [PDF]

PLOS Glob Public Health
Odhiambo DB, Akech D, Karia B, Kimani M, Sang S, Sigilai A, Voller S, Mataza C, Mang'ong'o D, Jalang'o R, Mandale M, Etyang AO, Scott JAG, Agweyu A, Kagucia EW.   +14 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Nationwide estimates of SARS-CoV-2 infection fatality rates and numbers needed to vaccinate for COVID-19 vaccines in 2024 in Austria. [PDF]

Eur J Clin Invest
Riedmann U, Sprenger M, Ioannidis JPA, Pilz S.   +3 more
europepmc   +1 more source

Selective Wettability–Driven Evaporation‐Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles

Small Methods, EarlyView.
ABSTRACT Timely detection of viral infections, particularly in settings outside centralized laboratories, is essential for controlling outbreaks. Small electrochemical biosensors are appealing because they are fast, require microliter sample volumes, and can be integrated into portable devices.
Pouya Soltan Khamsi, Shubhada K Chothe, Suresh V Kuchipudi, Aida Ebrahimi   +3 more
wiley   +1 more source