Results 251 to 260 of about 248,926 (292)
Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition [PDF]
Kidney International, 2001 BACKGROUND: Prostanoid products of the cyclo-oxygenase (COX) pathway of arachidonic acid metabolism modulate blood pressure (BP) and sodium homeostasis. Conventional non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit both COX isoforms (COX-1 and -2), cause sodium retention, exacerbate hypertension, and interfere with the efficacy of certain ...
Athirakul, Krairerk +4 more
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COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period
Molecular and Cellular Endocrinology, 1999Prostaglandins (PGs) produced by cyclooxygenase (COX) participate in many aspects of female reproduction. The two isoforms of cyclooxygenase, COX-1 and COX-2, have distinct expression patterns in the mouse uterus during the peri-implantation period and suggest their independent contribution to uterine PGs.
J, Reese +4 more
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Free Radical Biology and Medicine, 2011
A number of distinct cuproproteins of the mitochondrial inner membrane are required for the assembly of cytochrome oxidase (COX), thought to function in a "bucket brigade" fashion to provide copper to the Cu(A) and Cu(B) sites. In yeast, the loss of two these proteins, Sco1p and Cox11p, leads to respiratory deficiency and a specific inability to ...
Simona, Veniamin +3 more
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A number of distinct cuproproteins of the mitochondrial inner membrane are required for the assembly of cytochrome oxidase (COX), thought to function in a "bucket brigade" fashion to provide copper to the Cu(A) and Cu(B) sites. In yeast, the loss of two these proteins, Sco1p and Cox11p, leads to respiratory deficiency and a specific inability to ...
Simona, Veniamin +3 more
openaire +2 more sources
Identification of a novel deletion in SURF1 gene: Heterogeneity in Leigh syndrome with COX deficiency [PDF]
Mitochondrion, 2016 Leigh syndrome (LS) is a rare, progressive neurodegenerative mitochondrial disorder of infancy. It is a genetically heterogeneous disease. The mutations in SURF1 gene are the most frequently known cause. Here two cases of LS likely caused by SURF1 gene variants are reported: a 39-year-old male patient with a novel homozygous deletion (c.-11_13del), and
Carolina Ribeiro +2 more
exaly +4 more sources
Myoglobinuria and COX deficiency in a patient taking cerivastatin and gemfibrozil
Neurology, 2003The authors describe a patient who presented with myoglobinuria after starting cerivastatin-gemfibrozil therapy. Muscle histochemistry revealed ragged-red fibers and cytochrome c oxidase negative (COX) fibers, and biochemistry showed a defect of COX activity. Immunoblot analysis showed a 60% reduction of COX I and COX II polypeptides.
J, Arenas +14 more
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Facial Dysmorphism in Leigh Syndrome With SURF-1 Mutation and COX Deficiency
Pediatric Neurology, 2006Leigh syndrome is an inherited, progressive neurodegenerative disorder of infancy and childhood. Mutations in the nuclear SURF-1 gene are specifically associated with cytochrome C oxidase-deficient Leigh syndrome. This report describes two patients with similar facial features. One of them was a 2(1/2)-year-old male, and the other was a 3-year-old male
Adnan, Yüksel +4 more
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Molecular and Cellular Endocrinology, 1999
Erratum to ‘‘COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period’’ [Mol. Cell. Endocrinol. 150 (1999) 23–31] Jeff Reese , Naoko Brown , Bibhash C. Paria , Jason Morrow , Sudhansu K. Dey a a Department of Pediatrics, Uni6ersity of Kansas Medical Center, Kansas City, KS 66160-7338, USA b Molecular and Integrati6e ...
Jeff Reese +4 more
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Erratum to ‘‘COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period’’ [Mol. Cell. Endocrinol. 150 (1999) 23–31] Jeff Reese , Naoko Brown , Bibhash C. Paria , Jason Morrow , Sudhansu K. Dey a a Department of Pediatrics, Uni6ersity of Kansas Medical Center, Kansas City, KS 66160-7338, USA b Molecular and Integrati6e ...
Jeff Reese +4 more
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Mitochondrial Encephalomyopathy with COX Deficiency
2014Leigh syndrome, or subacute necrotizing encephalomyopathy, is a progressive neurological disorder characterized by specific neuropathological lesions in the brainstem and basal ganglia. The onset of symptoms occurs typically within 1 year of life (rarely in adolescence).
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Biochemical and Biophysical Research Communications, 2016
Epidemiologic studies indicate that chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a lower risk for developing Alzheimer's disease (AD). Because the primary mode of action of NSAIDs is to inhibit cyclooxygenase (COX) activity, it has been proposed that perturbed activity of COX-1 or COX-2 contributes to AD pathogenesis.
Sun Ah Park, Mary, Todd E Golde
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Epidemiologic studies indicate that chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a lower risk for developing Alzheimer's disease (AD). Because the primary mode of action of NSAIDs is to inhibit cyclooxygenase (COX) activity, it has been proposed that perturbed activity of COX-1 or COX-2 contributes to AD pathogenesis.
Sun Ah Park, Mary, Todd E Golde
exaly +3 more sources