Results 261 to 270 of about 248,926 (292)

Leigh Syndrome due to COX Deficiency

2014
Leigh syndrome, or infantile subacute necrotizing encephalopathy, is a severe early-onset progressive neurodegenerative disorder, characterized by symmetrical necrotic lesions in one or more areas of the central nervous system, including the brainstem, thalamus, basal ganglia, cerebellum, and spinal cord. The lesions are areas of demyelination, gliosis,
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COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice

NeuroReport, 2003
The primary lesion in Parkinson's disease is the death of dopaminergic neurons in the substantia nigra. The role of cyclooxygenase (COX)-2 in the etiology of Parkinson's disease was explored using COX-2 gene knockout mice. Mortality after injection of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP, a chemical known to cause parkinsonism in humans ...
Ho, SL, Ramsden, DB, Feng, Z, Li, D, Fung, PCW, Pei, Z   +5 more
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Low expression of COX‐2, reduced cumulus expansion, and impaired ovulation in SULT1E1‐deficient mice

The FASEB Journal, 2007
ABSTRACT The SULTlEl‐encoded estrogen sulfo‐transferase (EST) catalyzes sulfation of estrogen, resulting in its inactivation. Reduced fertility observed in SULT1E1 knockout (KO) female mice has previously been attributed to the deleterious effect of chronic exposure to high levels of circulating estrogen on ...
Eran, Gershon, Ariel, Hourvitz, Sharon, Reikhav, Ettie, Maman, Nava, Dekel   +4 more
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MR findings in Leigh syndrome with COX deficiency and SURF-1 mutations.

AJNR. American journal of neuroradiology, 2002
In a large number of patients with Leigh syndrome (LS) and cytochrome c oxidase (COX) deficiency, mutations of the SURF-1 gene were recently identified. The aim of the present study was to review the MR findings in patients with LS to verify if the genetically homogeneous patients with LS and SURF-1 mutations (LS SURF-1 patients) had a homogeneous MR ...
Farina, Laura, Chiapparini, Luisa, Uziel, Graziella, Bugiani, Marianna, Zeviani, Massimo, Savoiardo, Mario   +5 more
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Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus

Biochemical and Biophysical Research Communications, 2005
Diacylglycerol kinase (DGK) phosphorylates the second messenger diacylglycerol (DAG) to yield phosphatidic acid, two neural signaling elements that function to modulate synaptic activity. Of the nine mammalian DGK isotypes known, DGK epsilon (DGKepsilon) shows specificity for arachidonoyldiacylglycerol (20:4-DAG) and selectively contributes to modulate
Walter J, Lukiw, Jian-Guo, Cui, Alberto E, Musto, Brenda C, Musto, Nicolas G, Bazan   +4 more
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Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.

Cancer research, 2002
Nonsteroidal anti-inflammatory drugs are widely reported to inhibit carcinogenesis in humans and in rodents. These drugs are believed to act by inhibiting one or both of the known isoforms of cyclooxygenase (COX). However, COX-2, and not COX-1, is the isoform most frequently reported to have a key role in tumor development.
Howard F, Tiano, Charles D, Loftin, Jackie, Akunda, Christopher A, Lee, Judson, Spalding, Alisha, Sessoms, David B, Dunson, Eleanor G, Rogan, Scott G, Morham, Robert C, Smart, Robert, Langenbach   +10 more
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Late Postoperative Hemorrhage in a Patient With Undiagnosed COX-1 Deficiency After Third Molar Extractions

Journal of Oral and Maxillofacial Surgery, 2014
Oral maxillofacial surgeons direct invasive procedures that often cause significant bleeding. Uncontrolled hemorrhage is a rare, yet serious, complication that can be seen in patients with thrombocytopathy. Platelets have 3 distinct roles in coagulation: initial adhesion, phospholipid externalization, and platelet aggregation.(1) Several types of ...
Jesse C, Doscher, Fedele N, Volpe
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COX15 gene mutations causing COX deficiency and Leigh syndrome

2012
Cytochrome c oxidase (COX) deficiency is one of the most frequently observed abnormalities of the OXPHOS system. Different clinical phenotypes are seen in patients with COX deficiencies. COX is the terminal complex of the mitochondrial respiratory chain and catalyses the reduction of molecular oxygen to water.
Vancampenhout, Kim, De Meirleir, Linda, Van Dooren, Sonia, Smet, Joél, Van Coster, Rudy, Ullmann, Urielle, Lissens, Willy, Bonduelle, Mary-Louise, Seneca, Sara   +8 more
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Calcium deficiency of ‘Cox's Orange’ apple trees during the fruit growth period

Scientia Horticulturae, 1980
Abstract In a pot experiment with apple trees, cultivar ‘Cox's Orange’, Ca was omitted in the nutrient solution for periods of different length. Trees lacking Ca in the latest 2 3 of the growth period contained 42 mg kg−1 Ca in the fruits, which is 21% below control.
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Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice

American Journal of Physiology-Renal Physiology, 2005
The present study was undertaken to determine whether the severity of renal failure or hypertension in homozygous cyclooxygenase (COX)-2-deficient (COX-2−/−) mice affected by genetic background or gender. COX-2 deletion was introduced into three congenic genetic backgrounds, 129/Sv (129/COX-2−/−), C57/BL6 (C57/COX-2−/−), and BALB/c (BALB/COX-2−/−), by ...
Yang, T., Huang, Y., Ye, W., Hansen, Pernille B. Lærkegaard, Schnermann, J., Briggs, J.   +5 more
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