Results 81 to 90 of about 248,926 (292)

Protein Nitration in Patients with Mitochondrial Diseases

Antioxidants
Mitochondrial diseases are complex disorders caused by nuclear or mitochondrial DNA mutations, leading to oxidative phosphorylation deficiency and excessive production of reactive oxygen species (ROS).
Jomênica B. Livramento, Gabriela S. Rodrigues, Jean Faber, Luis A. de Souza Filho, Felipo V. Moura, Camila D. S. Barros, Wladimir B. V. R. Pinto, Beny Schmidt, Acary S. B. Oliveira, Beatriz H. Kiyomoto, Célia H. Tengan   +10 more
doaj   +1 more source

Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice

Journal of Pharmacological Sciences, 2020
Folate deficiency has been suggested as a risk factor for depression in preclinical and clinical studies. Several hypotheses of mechanisms underlying folate deficiency-induced depressive symptoms have been proposed, but the detailed mechanisms are still ...
Shoji Nishida, Ryota Araki, Akihiro Baba, Sota Asari, Shin Tachibana, Yuki Nakajima, Arimi Iwakumo, Takeshi Yabe   +7 more
doaj   +1 more source

Are interstitial cells of Cajal involved in mechanical stress-induced gene expression and impairment of smooth muscle contractility in bowel obstruction? [PDF]

PLoS ONE, 2013
The network of interstitial cells of Cajal (ICC) is altered in obstructive bowel disorders (OBD). However, whether alteration in ICC network is a cause or consequence of OBD remains unknown.
Chester C Wu, You-Min Lin, Jerry Gao, John H Winston, Leo K Cheng, Xuan-Zheng Shi   +5 more
doaj   +1 more source

DO IT Trial: vitamin D Outcomes and Interventions in Toddlers - a TARGet Kids! randomized controlled trial. [PDF]

, 2014
BackgroundVitamin D levels are alarmingly low (<75 nmol/L) in 65-70% of North American children older than 1 year. An increased risk of viral upper respiratory tract infections (URTI), asthma-related hospitalizations and use of anti-inflammatory ...
Birken, Catherine S, Borkhoff, Cornelia M, Hoch, Jeffrey S, Loeb, Mark B, Macarthur, Colin, Maguire, Jonathon L, Mamdani, Muhammad, Mazzulli, Tony, Parkin, Patricia C, TARGet Kids! Collaboration, Thorpe, Kevin   +10 more
core   +3 more sources

Purkinje cell COX deficiency and mtDNA depletion in an animal model of spinocerebellar ataxia type 1 [PDF]

Journal of Neuroscience Research, 2018
AbstractSpinocerebellar ataxias (SCAs) are a genetically heterogeneous group of cerebellar degenerative disorders, characterized by progressive gait unsteadiness, hand incoordination, and dysarthria. Ataxia type 1 (SCA1) is caused by the expansion of a CAG trinucleotide repeat in the SCA1 gene resulting in the atypical extension of a polyglutamine ...
M. Ripolone, V. Lucchini, D. Ronchi, G. Fagiolari, A. Bordoni, F. Fortunato, S. Mondello, S. Bonato, M. Meregalli, Y. Torrente, S. Corti, G. P. Comi, M. Moggio, M. Sciacco.   +13 more
openaire   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Development and Management of Canine Adverse Food Reactions and its Connections to the Grain-Free Dog Food Movement [PDF]

, 2020
Canine Adverse Food Reactions include immunologically-mediated food allergies as well as non-immunological food intolerances. Although popular belief holds grains are responsible for AFR, the majority are aggravated by the common protein sources found in
Dunn, Savannah
core   +1 more source

Hypoxia‐induced angiogenesis is suppressed in COX‐2 deficient mouse brain cortex

The FASEB Journal, 2007
Exposure to mild hypoxia induces angiogenesis in rat and mouse brain through cooperation of the HIF‐1 transcription factor‐vascular endothelial growth factor and the COX‐2‐angiopoietin 2 signaling pathways. To see if both systems were required for angiogenesis, 3 month old COX‐2 deficient mice (Jackson Laboratories) and their wild ...
Xiaoyan Sun, Mary P Modesitt, Constantinos P Tsipis, Joseph C LaManna   +3 more
openaire   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Mannan-binding lectin suppresses growth of hepatocellular carcinoma by regulating hepatic stellate cell activation via the ERK/COX-2/PGE2 pathway

OncoImmunology, 2019
Mannan binding lectin (MBL), initially known to activate the complement lectin pathway and defend against infection, was recently shown to be potentially involved in the development of several types of cancer; however, its exact role in cancers ...
Junru Li, Huifang Li, Yu Yu, Yan Liu, Yunzhi Liu, Qiang Ma, Liyun Zhang, Xiao Lu, Xiang-yang Wang, Zhengliang Chen, Daming Zuo, Jia Zhou   +11 more
doaj   +1 more source