Results 101 to 110 of about 23,378,967 (385)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Cox Model-Based Workflow for Increased Accuracy in Activity-Travel Patterns Generation

Applied Sciences
Understanding how people spend time on daily activities is key to modeling travel behavior. However, accurately estimating the duration of these activities remains a significant challenge, especially when generating synthetic activity-travel data.
Dionysios Katsaitis, Dimitrios Rizopoulos, Konstantinos Gkiotsalitis   +2 more
doaj   +1 more source

Uncertain Box-Cox Regression Analysis With Rescaled Least Squares Estimation

IEEE Access, 2020
Under the uncertain statistical framework by Liu [19], there is still a lack of an effective fitting method for uncertain linear models with Box-Cox transformation of response variables.
Shiqin Liu, Liang Fang, Zaiying Zhou, Yiping Hong   +3 more
doaj   +1 more source

Forecasts of non-Gaussian parameter spaces using Box-Cox transformations

, 2011
Forecasts of statistical constraints on model parameters using the Fisher matrix abound in many fields of astrophysics. The Fisher matrix formalism involves the assumption of Gaussianity in parameter space and hence fails to predict complex features of ...
A. N. Taylor, Amara, B. Joachimi, Bartelmann, Bergé, Bond, Box, Cappé, Daniel, Eisenstein, Fisher, Frommert, Fry, Guzik, Hartlap, Hoekstra, Joachimi, Joachimi, Kaiser, Kiessling, Kiessling, Kosowsky, Munshi, Neyrinck, Peacock, Schneider, Schrabback, Scoccimarro, Seo, Smith, Takada, Taylor, Tegmark, Tegmark, Velilla, Wraith   +35 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Prediction of recurrence-free survival in patients with renal cell carcinoma and tumor thrombosis of the renal and inferior vena cava of levels I–II using an extended Cox model and machine learning methods

Наука и инновации в медицине
Aim – to compare the predictive accuracy of Cox regression and machine learning (ML) methods regarding recurrence-free survival in patients with locally advanced renal cell carcinoma after radical treatment.
Musabek K. Mirzabekov, Nikolai D. Tikhonskii, Mikhail I. Shkolnik, Oleg A. Bogomolov, Nina V. Trukhacheva   +4 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Survival analysis of Kasturi tobacco plants in Jember district using the stratified cox and extended cox models.

MethodsX
In 2022, tobacco was the top export commodity, generating $106.3 million in sales. East Java Province contributes significantly to Indonesia's tobacco production, with an annual output of 188.6 thousand tons.
Angga Iryanto Pratama, Dwi Rantini, Ratih Ardiati Ningrum, Arip Ramadan, Fazidah Othman   +4 more
doaj   +1 more source

Bond and CDS Pricing via the Stochastic Recovery Black-Cox Model

, 2017
Building on recent work incorporating recovery risk into structural models by Cohen & Costanzino (2015), we consider the Black-Cox model with an added recovery risk driver. The recovery risk driver arises naturally in the context of imperfect information
Albert Cohen, Nick Costanzino
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source