Results 241 to 250 of about 1,497,781 (343)

Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportional. [PDF]

BMC Med Res Methodol
Gu T, Chen Z, Soon YY, Wee J, Tai BC.
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Cox Proportional Hazards Model for Event-Free Survival (Total Mortality and Heart Transplantation)^*.

Maria Tereza Sampaio de Sousa Lira (21169240), Silas Ramos Furquim (21169243), Daniel Catto de Marchi (21169246), Pamela Camara Maciel (21169249), Rafael Cavalcanti Tourinho Dantas (21169252), Bruno Biselli (4957378), Paulo Roberto Chizzola (4846249), Robinson Tadeu Munhoz (21169255), Felix José Alvarez Ramires (10372223), Barbara Maria Ianni (9091697), Fábio Fernandes (383385), Silvia Moreira Ayub-Ferreira (4846234), Eduardo Gomes Lima (4895998), Edimar Alcides Bocchi (7856090)   +13 more
openalex   +1 more source

Software Application Profile: CaseCohortCoxSurvival-an R package for case-cohort inference for relative hazard and pure risk under the Cox model. [PDF]

Int J Epidemiol
Etiévant L, Gail MH.
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Analyzing Left-Truncated Samples with the Cox Model in the Presence of Missing Covariates. [PDF]

Stat Biosci
Vazquez O, Locke HM, Xie SX.
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Adjusted^ cox proportional hazards models for mortality by FEV₁ index deciles.

Stephen T. Russell (9315250), Mohleen Kang (21370171), Jordan A. Kempker (21370174)   +2 more
openalex   +1 more source

NOTIFICATION : Does the Cox Proportional Hazards Model Accurately Reflect the Dynamics of Kidney Outcomes? An Exploration of Superior Alternatives [PDF]

openalex   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source