Results 271 to 280 of about 402,477 (353)

Avidity‐Based Capture of PD‐L1‐Expressing Exosomes via Dendrimer–Peptide Conjugates: A Nanoengineered Platform for Enhanced Prediction of Immunotherapy Response

Advanced Science, EarlyView.
This study introduces a dendrimer‐peptide conjugate platform (G7‐pPDL1) for avidity‐based capture of PD‐L1‐expressing exosomes. The system exhibits enhanced binding kinetics and exosome capture efficiency, enabling accurate prediction of immunotherapy outcomes.
Jiah Lee, Dongjun Shin, Chae Yeon Son, Hanbit Kang, Jung Hyun Choi, Hyun Sung Park, Seha Bang, Lucia Kim, Tae Hee Lee, Hyuk Soo Eun, Michael J Poellmann, Woo‐jin Jeong, Dong Hyung Kim, Jun Hyeok Lim, Seungpyo Hong, Jiyoon Bu   +15 more
wiley   +1 more source

Cox proportional hazard-model application: time to cervical cancer screening among women living with HIV in South Africa [PDF]

Marcus Hollington
openalex   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

Advanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang, Xianli Zhang, Yuanyuan Zhou, Shuyi Lin, Yuting Fu, Haiping Liu, Qiongdan Gao, YanHong Xiao, Zhao Yin, Shuang Liu, Kexiu Huang, Suqi Deng, Juan Du, Hui Zeng, Jia Wang, Jinping Zheng, Qinghua Zhou, Tianfeng Chen, Xiaoling Gao, Zhenyu Ju, Bo Liu   +20 more
wiley   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source

Product differentiation in the fruit industry: Lessons from trademarked apples

Agribusiness, EarlyView.
Abstract We derive price premiums for patented or trademarked apple varieties, also known as “club apples,” compared to open‐variety apples. We use an expansive retail scanner dataset, along with unique data on apple taste characteristics, to estimate monthly club apple premiums for 2008–2018.
Modhurima Dey Amin, Syed Badruddoza, Jill J. McCluskey, Gregory Astill   +3 more
wiley   +1 more source

Supply chain risk in grain trading: Inventories as real options for shipping grain

Agribusiness, EarlyView.
Abstract Integrating trading and logistics is an important challenge in commodity trading. Trading and logistics are strategic decisions and are integral to most commodities including grain shipping by rail, in addition to other modes (barges, ocean shipping). There are substantial risks, such as the ordering and placement of rail cars.
William W. Wilson, Jesse Klebe
wiley   +1 more source

Conditional Survival for Pancreas Graft and Its Associated Factors After Pancreas Transplantation

Annals of Gastroenterological Surgery, EarlyView.
This study investigates conditional survival (CS) for pancreas grafts in recipients of pancreas transplantation (PTx) in Japan, using data from 526 cases. Findings reveal that CS increases over time post‐transplant, offering a more optimistic long‐term prognosis than traditional actuarial survival. While donor sex and PTx procedure type influence early
Yoshito Tomimaru, Toshinori Ito, Tetsuhisa Kitamura, Takashi Kenmochi, Yuichiro Doki, Hidetoshi Eguchi   +5 more
wiley   +1 more source

Prognostic Impact of Hepatectomy Versus Radiofrequency Ablation for Non‐Small Hepatocellular Carcinoma (2–3 cm): A Case‐Matched Study

Annals of Gastroenterological Surgery, EarlyView.
This study aims to elucidate prognostic outcomes of hepatectomy versus RFA for primary 2–3 cm HCC. Hepatectomy may offer superior prognostic benefits, especially in those with elevated AFP levels. The local recurrence rate in hepatectomy is significantly lower than RFA.
Yuki Kitano, Hiromitsu Hayashi, Takumi Tanizaki, Yoshiyuki Tagayasu, Takashi Matsumoto, Rumi Itoyama, Shigeki Nakagawa, Hirohisa Okabe, Masaaki Iwatsuki   +8 more
wiley   +1 more source