Results 141 to 150 of about 3,057,200 (307)

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Using Quantile Regression for Duration Analysis [PDF]

Quantile regression methods are emerging as a popular technique in econometrics and biometrics for exploring the distribution of duration data. This paper discusses quantile regression for duration analysis allowing for a flexible specification of the ...
Wilke, Ralf A., Fitzenberger, Bernd
core  

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Predictive value of expression of the CXCR4/Akt signaling pathway in the peripheral blood for brain glioma

Romanian Journal of Laboratory Medicine
Background: The aim of this study was to investigate the activation of the C-X-C chemokine receptor type 4 (CXCR4)/Akt signaling pathway in the peripheral blood of individuals diagnosed with brain glioma and assess its potential as a predictive marker.
Zou Xueli
doaj   +1 more source

Capturing surgical site infection after hip fracture surgery: insights from linked routine data

Bone & Joint Open
Aims: To evaluate the incidence, timing, and capture of surgical site infections (SSIs) following hip fracture surgery using routinely collected primary and secondary care datasets, and to assess the limitations of using such resources to identify SSIs ...
James Masters, David Metcalfe, Matthew L. Costa, Andrew Judge   +3 more
doaj   +1 more source

Cox regression analysis.

, 2015
Cox regression analysis.
Michael Ghadimi (746711), Ashham Mansur (746708), Tim Beissbarth (4037675), Martin Bauer (746715), Aron Frederik Popov (746714), Mladen Tzvetkov (746713), Maximilian Steinau (746710), Ingo Bergmann (746712), Benjamin Liese (746709), José Hinz (746716)   +9 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Homespun quilt, by Elvira Pamela Mills Cox

Image of Homespun quilt created circa 1860-1880 by Elvira Pamela Mills Cox. Also includes questionnaires describing the quilt completed by Nancy Cox Mackay as part of the Utah Quilt Guild\u27s documentation days held from 1988-1994.
Cox, Elvira Pamela Mills
core  

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Materiales didáctico-científicos del profesorado del IES de Cox

, 2008
En el CD se presentan documentos con extensión .doc (Word) y .ppt (Power Point)Materiales derivados de la labor didáctico-científica y de investigación del profesorado del IES de Cox (Alicante), integrados por actividades destinadas al alumnado de ...
López Rivera, Francisco, Pérez Zarauz, María Encarnación, Carmona Gnecco, Juan Antonio   +2 more
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