Results 181 to 190 of about 851,409 (271)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Data-driven prior elicitation for Bayes factors in Cox regression for nine subfields in biomedicine. [PDF]

PLoS One
Linde M, Jochim L, Tendeiro JN, van Ravenzwaaij D.   +3 more
europepmc   +1 more source

Cox regression model with randomly censored covariates

, 2019
Folefac Atem, Roland Matsouaka, Vincent Zimmern   +2 more
openalex   +1 more source

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

Advanced Science, EarlyView.
This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani, Eric Reed, Kevin B Chandler, Prisma Lopez, Hannah Lords, Harold Bae, Catherine E Costello, Matthew Au, Lingyi Lynn Deng, Mengze Li, Qingyan Xiang, Heeju Noh, Lance Pflieger, Cory Funk, Noa Rappaport, Marianne Nygaard, Meghan I Short, Michael Brent, Stefano Monti, Stacy L Andersen, Thomas T Perls   +20 more
wiley   +1 more source

Comparison of machine learning and Cox regression models for prognostic analysis in hepatocellular carcinoma patients with distant metastasis. [PDF]

Surg Open Sci
Li H, Wang J, Ming X, Zhou M, Zhou L.
europepmc   +1 more source

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science, EarlyView.
LZU‐WZLYCS01 is a novel FGFR3‐targeting ADC for bladder cancer with 7‐ethyl‐9‐fluorocamptothecin (A2) as its cytotoxic payload. LZU‐WZLYCS01 intracellularly releases A2, which targets MAD2L1 to activate the cGAS‐STING pathway and induce tumor cell apoptosis.
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
wiley   +1 more source

Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study. [PDF]

Discov Oncol
Chokkakula S, Chong S, Yang YY, Huang L, Qian Y, Sun Q, Xia S, Zhang X, Yong J, Pathakumari B, Prabakaran DS, Si IC, Ou Y, Yin C.   +13 more
europepmc   +1 more source

Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression

, 2021
Fatemeh Homaei Shandiz, Vahid Ghavami, Nooshin Akbari Sharak, Mohammad Saghafi, Saeedeh Hajebi Khaniki   +4 more
openalex   +2 more sources

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

Advanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng, Ruijie Xie, Bernd Holleczek, Hermann Brenner, Ben Schöttker   +4 more
wiley   +1 more source

Corrigendum: Prognostic impact of nutritional indicators based on Lasso-Cox regression for non-muscle-invasive bladder cancer. [PDF]

Front Nutr
Ye J, Xie Y, Ran B, Han P.
europepmc   +1 more source