Results 181 to 190 of about 871,313 (293)

Construction and assessment of a predictive framework for Enterobacterales bloodstream infection in real-world adult onco-hematology patients using Lasso-Cox regression. [PDF]

Antimicrob Agents Chemother
Cui Y, Feng X, Wang J, Liu L, Zhang L, Lin Q, Pan L, Zhen S, Fan Y, Chen X, Zhang T, Mi Y, Xiao Z, Jiang E, Han M, Wang J, Feng S.   +16 more
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study. [PDF]

Discov Oncol
Chokkakula S, Chong S, Yang YY, Huang L, Qian Y, Sun Q, Xia S, Zhang X, Yong J, Pathakumari B, Prabakaran DS, Si IC, Ou Y, Yin C.   +13 more
europepmc   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Multivariate Cox regression analysis of prognostic genes and therapeutic mechanisms of gastric cancer. [PDF]

Discov Oncol
Xiao Y, Zhong Z, Yang C, Lin Z.
europepmc   +1 more source

Threshold‐Voltage Modulation and N2O Plasma Passivation for Enhanced Retention and Memory Window in Capacitorless 2T0C DRAM Oxide Thin‐Film Transistors

Advanced Science, EarlyView.
Al:ITZO‐based capacitorless 2T0C DRAMs are realized by combining N2O plasma‐induced defect modulation with read‐transistor W/L optimization to suppress leakage and stabilize data storage. This device‐level engineering enables zero‐bias hold operation, retention times exceeding 1000 s, and a 13‐fold expansion of the memory window, demonstrating a ...
Chahwan Yang, Mirinae Lee, Junghoon Han, Sooji Nam   +3 more
wiley   +1 more source

Corrigendum: Prognostic impact of nutritional indicators based on Lasso-Cox regression for non-muscle-invasive bladder cancer. [PDF]

Front Nutr
Ye J, Xie Y, Ran B, Han P.
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Demographic and clinical predictors of treatment outcomes in invasive lobular carcinoma breast cancer: insights from Cox regression analysis. [PDF]

Discov Oncol
Kaindal S, Venkataramana B.
europepmc   +1 more source