Advanced Science, EarlyView.An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu +11 more
wiley +1 more source
Prognostic impact of nutritional indicators based on Lasso-Cox regression for non-muscle-invasive bladder cancer. [PDF]
Front NutrYe J, Xie Y, Ran B, Han P.
europepmc +1 more source
Advanced Science, EarlyView.This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen +5 more
wiley +1 more source
Comparison of random survival forest and Cox regression for long-term prognosis of pediatric Wilms tumor: based on the SEER database and external validation cohort from China. [PDF]
Discov OncolFang H +9 more
europepmc +1 more source
Predictors for independent external validation of cardiovascular risk clinical prediction rules: Cox proportional hazards regression analyses [PDF]
, 2018 Jong-Wook Ban +2 more
openalex +1 more source
Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression
Advanced Science, EarlyView.Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li +4 more
wiley +1 more source
Robust inverse probability weighted estimators for doubly truncated Cox regression with closed-form standard errors. [PDF]
Lifetime Data AnalVazquez O, Xie SX.
europepmc +1 more source
Weighted Estimation in Cox Regression Model: An Application to Breast Cancer Data
, 2013 Nihal Ata, Haydar Demirhan
openalex +1 more source
Variable selection in Cox regression models with varying coefficients
, 2012 Toshio Honda, Wolfgang Karl Härdle
openalex +1 more source
Advanced Science, EarlyView.It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li +9 more
wiley +1 more source