Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh +19 more
wiley +1 more source
Maternal palmitoleic acid supplementation attenuates neurodegenerative programming in aged offspring exposed to gestational diabetes. [PDF]
Kawaharada R +5 more
europepmc +1 more source
ABSTRACT Background The increasing burden of oral diseases in low‐ and middle‐income countries (LMICs) and limited access to and affordability of oral care disproportionately impact disadvantaged groups. Oral health research has been dominated by professional academic perspectives with limited contribution from the communities involved. The aim of this
Carol C. Guarnizo‐Herreño +9 more
wiley +1 more source
Signal Detection Using Change Point Analysis to Identify Safety Signals from Spontaneous Reports in Aortic Stent Grafts in Japan. [PDF]
Takahashi K +8 more
europepmc +1 more source
Licence Loss: Revocations of Residential Care Licences in Four Nordic Countries
ABSTRACT With placement in residential care, society assumes overall responsibility for a child's daily care, well‐being and development. How public authorities respond to poor care quality is of crucial importance. To guarantee quality care and minimise risks, welfare states increasingly develop different mechanisms and systems to supervise out‐of ...
David Pålsson +5 more
wiley +1 more source
An oral rotavirus-vectored vaccine confers protection against <i>Clostridium perfringens</i> and rotavirus. [PDF]
Wang J +14 more
europepmc +1 more source
Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta +24 more
wiley +1 more source
Isolated cerebellopontine angle neurosarcoidosis mimicking meningioma: a diagnostic pitfall. Illustrative case. [PDF]
Karaman N +3 more
europepmc +1 more source
DFT Calculation-Assisted Virtual Screening to Refine Chiral Phosphoric Acid-Catalyzed Allylboration Enabling Organocatalytic Synthesis of Tetrafibricin C21-C40 Fragment. [PDF]
Umemiya S, Hirata T, Terada M.
europepmc +1 more source

