Results 121 to 130 of about 37,359 (216)

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Circulating tumor DNA and Response Evaluation Criteria In Solid Tumors: ctDNA-RECIST proof-of-concept in HER2-positive metastatic breast cancer. [PDF]

J Exp Clin Cancer Res
Fabi A, Giordani E, Ricciardi E, Arpino G, Allegretti M, Ferretti G, Omarini C, Zambelli A, Mandoj C, Botticelli A, Bria E, Gori S, Carbognin L, Paris I, Scambia G, Cognetti F, Giannarelli D, Giacomini P.   +17 more
europepmc   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Continuing Professional Development – Radiation Therapy

Journal of Medical Radiation Sciences, EarlyView.
wiley   +3 more sources

CKAAKN peptide-conjugated long-circulating nanoliposomes for the targeted delivery of oridonin to pancreatic cancers. [PDF]

Sci Rep
Zhang F, Luo K, Xuan S, Chen T, Chen Z, Yang J, Zhou Y, Feng T, Zhu Y, Wang Z.   +9 more
europepmc   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Development of a competitive immunoassay platform for quantifying the oligonucleotide products of nucleotide excision repair in UV-irradiated cells. [PDF]

Nucleic Acids Res
Kim GH, Kwon HJ, Kim Y, Kemp MG, Choi JH.   +4 more
europepmc   +1 more source

Continuing Professional Development — Medical Imaging

Journal of Medical Radiation Sciences, EarlyView.
wiley   +3 more sources

Chiral‐Induced Spin‐Polarized Molecular Switching in a Magneto‐Controlled 2D System using Electrical Readouts

Small, EarlyView.
Through molecular engineering, an unconventional chiral 2D platform based on covalently functionalized 2D germanane achieved magneto‐controlled spin‐dependent electron transport, which can be further tuned through the enantiomeric configuration of the chiral ligand.
Yiming Lei, Ángel Campos‐Lendínez, Irena Spasojevic, Xavier Sala, Jordi García‐Antón, Jordi Sort, Jose Muñoz   +6 more
wiley   +1 more source

CPD-1 can compensate for EGL-21 to process neuropeptides. [PDF]

MicroPubl Biol
Khawand DC, Clippinger AK, Ailion M.
europepmc   +1 more source