Results 51 to 60 of about 51,179 (262)

Confined bioprinting and culture in inflatable bioreactor for the sterile bioproduction of tissues and organs

Scientific Reports
The future of organ and tissue biofabrication strongly relies on 3D bioprinting technologies. However, maintaining sterility remains a critical issue regardless of the technology used.
Alexandre Dufour, Lucie Essayan, Céline Thomann, Emma Petiot, Isabelle Gay, Magali Barbaroux, Christophe Marquette   +6 more
doaj   +1 more source

The Potential Therapeutic Agent Mepacrine Protects Caco-2 Cells against Clostridium perfringens Enterotoxin Action

mSphere, 2017
Clostridium perfringens enterotoxin (CPE) causes the diarrhea associated with a common bacterial food poisoning and many antibiotic-associated diarrhea cases.
John C. Freedman, Matthew R. Hendricks, Bruce A. McClane   +2 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

(Fe4N/GaN)@GC: A Bifunctional Electrocatalyst for High‐Performance Rechargeable Zinc‐Air Batteries

Advanced Science, EarlyView.
This work demonstrates that an unprecedented Fe4N/GaN heterostructure, stabilized by a graphitized carbon shell, induces interfacial charge redistribution and optimizes oxygen‐intermediate adsorption, enabling highly efficient bifunctional ORR/OER electrocatalysis for rechargeable zinc‐air batteries.
Xin‐Yuan Wei, Sai‐Sai Xie, Xia‐Li Ding, Yuan‐Qi Zhai, Sen Yu, Xiang‐Quan Hu, Rongqian Wu, Jintao Lu, Yan‐Zhen Zheng   +8 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Overcoming Interfacial Hurdles in Solid‐State Aluminum Batteries for Safe and Energy‐Dense Storage

Advanced Science, EarlyView.
Solid‐state aluminum batteries (SSABs) promise high energy density and intrinsic safety but face severe solid–solid interfacial challenges. This review reveals the three core hurdles—anode passivation, cathode contact loss, and electrolyte grain boundary resistance and discusses strategies including artificial interphases, alloying, and composite ...
Yunlei Wang, Xiaogang Zhang, Mingguang Wang, Yifan Wu, Shitao Dou, Taibin Wu   +5 more
wiley   +1 more source

Trends in antipsychotic drug utilisation and indication in the paediatric population: a nationwide cohort study in Sweden

BMJ Mental Health
Background Data on antipsychotic use for the Swedish paediatric population is limited.Objective We assessed the incidence, likely indication and extent of off-label antipsychotic use among children and adolescents in Sweden.Methods In this nationwide ...
Björn Pasternak, Viktor Wintzell, Johan Reutfors, Richeek Pradhan, Karl-Hermann S Kamgang   +4 more
doaj   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source

Integration of multi-modal monitoring for dynamic control of large-scale 3D tissue bioreactors

Scientific Reports
The translation of tissue engineering toward clinically relevant large-scale biofabrication requires continuous and non-invasive monitoring of tissue maturation.
Laura Chastagnier, Sarah Pragnere, Yilbert Gimenez, Celine Loubière, Lucie Essayan, Kleanthis Mazarakis, Timo Schmidberger, Eric Olmos, Simon Auguste Lambert, Christophe A. Marquette, Emma Petiot   +10 more
doaj   +1 more source

RIP1, RIP3, and MLKL Contribute to Cell Death Caused by Clostridium perfringens Enterotoxin

mBio, 2019
Clostridium perfringens type F strains cause gastrointestinal disease when they produce a pore-forming toxin named C. perfringens enterotoxin (CPE). In human enterocyte-like Caco-2 cells, low CPE concentrations cause caspase-3-dependent apoptosis, while ...
Archana Shrestha, Iman Mehdizadeh Gohari, Bruce A. McClane   +2 more
doaj   +1 more source