Results 31 to 40 of about 2,165 (170)

Synthetic and analytical method establishment of 3-(4-chlorophenyl)-7-[JP]\[2-(piperazin-l-yl)ethoxy\]-4H-chromen-4-one

Journal of Hebei University of Science and Technology, 2022
In order to solve the problem of insufficient antitumor activity of natural daidzein (DAI),the 4 'and 7 positions of DAI were modified.Firstly,3-(4-chlorophenyl)-7-hydroxy-4H-chromen-4-one was prepared from resorcinol and p-chlorophenylacetic acid by ...
Mengqiang LIAN, Yachen LIU, Chunyan GUO
doaj   +1 more source

HBimmCue: A Versatile Fluorescent Probe for Multi-Scale Imaging of Lipid Polarity and Membrane Order in Inner Mitochondrial Membrane. [PDF]

Adv Sci (Weinh)
HBimmCue is introduced as a fluorescent probe that detects lipid polarity changes in the inner mitochondrial membrane (IMM), reflecting cellular respiration levels. Using fluorescence lifetime imaging (FLIM), IMM lipid heterogeneity is uncovered across various scales, from nanoscale structures in mitochondria to cellular and developmental models ...
Gao S, Sun J, Hou Y, Ge X, Shi M, Zheng H, Zhang Y, Li M, Gao B, Xi P.   +9 more
europepmc   +2 more sources

Neuropathic Pain as Main Manifestation of POLG-Related Disease: A Case Report

Frontiers in Neurology, 2022
Mutations in nuclear-encoded genes that are involved in mitochondrial DNA replication and maintenance (e.g., POLG) have been associated with chronic progressive external ophthalmoplegia (CPEO) phenotype.
Melanie Lang-Orsini, Paloma Gonzalez-Perez   +1 more
doaj   +1 more source

Antimicrobial Activity the Essential Oil from Croton pluriglandulosus Carn. Leaves against Microorganisms of Clinical Interest

Journal of Fungi, 2023
Multiresistant pathogens pose a serious threat to human health. The genus Candida is one class of human pathogenic yeasts responsible for infections affecting healthy and immunocompromised patients.
Rayara J. P. Carvalho, Pedro F. N. Souza, Ellen A. Malveira, Nilton A. S. Neto, Romério R. S. Silva, Gabriel L. C. Melo, Ayrles F. B. Silva, Leandro B. Lima, Cynthia C. de Albuquerque, Rafael W. Bastos, Gustavo H. Goldman, Cleverson D. T. de Freitas   +11 more
doaj   +1 more source

A case of chronic progressive external ophthalmoplegia presenting with central neurogenic hyperventilation

Brain Disorders, 2022
We report a female patient with typical chronic progressive external ophthalmoplegia (CPEO) presented with central neurogenic hyperventilation (CNH), which is characterized by sustained hyperventilation during awake and sleep.
Mariko Sano, Tomoyo Shimada, Anri Sakurai, Yu-ichi Goto, Taiji Tsunemi, Nobutaka Hattori   +5 more
doaj   +1 more source

Retrieval of High Added Value Natural Bioactive Coumarins from Mandarin Juice-Making Industrial Byproduct

Molecules, 2021
Cold pressed essential oil (CPEO) of mandarin (Citrus reticulata Blanco), a by-product of the juice-making industrial process known to contain large amounts of polymethoxyflavones, was exploited for its content in high added value natural coumarins.
Eleni D. Myrtsi, Apostolis Angelis, Sofia D. Koulocheri, Sofia Mitakou, Serkos A. Haroutounian   +4 more
doaj   +1 more source

Low Prevalence of Cardiomyopathy in Patients with Mitochondrial Disease and Neurological Manifestations

Journal of Cardiovascular Development and Disease, 2022
Patients with mitochondrial diseases can develop cardiomyopathy but with variable expressivity and penetrance. Our prospective study enrolled and evaluated a cohort of 53 patients diagnosed with chronic progressive ophthalmoplegia (CPEO, n = 34), Kearns ...
Anish Nikhanj, Jesi Bautista, Zaeem A. Siddiqi, Cecile L. Phan, Gavin Y. Oudit   +4 more
doaj   +1 more source

Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy [PDF]

Brazilian Journal of Medical and Biological Research, 2015
Exercise intolerance due to impaired oxidative metabolism is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still uncertain whether L-carnitine supplementation is beneficial for patients with MM.
A.C. Gimenes, D.M. Bravo, L.M. Nápolis, M.T. Mello, A.S.B. Oliveira, J.A. Neder, L.E. Nery   +6 more
doaj   +3 more sources

Extraocular muscle atrophy and central nervous system involvement in chronic progressive external ophthalmoplegia.

PLoS ONE, 2013
BackgroundChronic progressive external ophthalmoplegia (CPEO) is a classical mitochondrial ocular disorder characterised by bilateral progressive ptosis and ophthalmoplegia.
Cynthia Yu-Wai-Man, Fiona E Smith, Michael J Firbank, Grant Guthrie, Stuart Guthrie, Grainne S Gorman, Robert W Taylor, Douglass M Turnbull, Philip G Griffiths, Andrew M Blamire, Patrick F Chinnery, Patrick Yu-Wai-Man   +11 more
doaj   +1 more source

Videographic analysis of blink dynamics in patients with chronic progressive external ophthalmoplegia, myogenic ptosis, and facial nerve palsy using smartphone camera: A comparative analysis

Health Science Reports, 2023
Background and Aims Congenital myogenic ptosis (CMP), chronic progressive external ophthalmoplegia (CPEO), and facial nerve palsy (FNP) are among the disorders which can seriously affect the blink dynamics of patients. Smartphone videography is a simple,
Nazanin Hedayati Amlashi, Mohammad Taher Rajabi, Mahan Shafie, Somayeh Heidarzadeh, Mohammad Bagher Rajabi, Seyedeh Simindokht Hosseini, Ainaaz Haadi, Parnian Soltani   +7 more
doaj   +1 more source