Results 91 to 100 of about 178,131 (286)

Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory [PDF]

, 2018
Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an endogenous lysophospholipid with ...
Castilla Ortega, María Estela, Estivill-Torrús, Guillermo, Gil Rodríguez, Sara, Ladrón de Guevara-Miranda, David, Moreno-Fernández, Román D., Pavón, Francisco Javier, Rodríguez de Fonseca, Fernando, Rosell-del-Valle, Cristina, Santin-Nuñez, Luis Javier, Serrano, Antonia   +9 more
core  

Refining Detection of Subclinical Epileptiform Activity in Alzheimer's Disease: A Case–Control Study and Call for a Consensus

Annals of Neurology, EarlyView.
Objective Sleep‐predominant network hyperexcitability is increasingly recognized as a potential disease‐accelerating comorbidity in Alzheimer's disease (AD). However, its prevalence and risk‐factors remain debated, largely due to cohort‐specific and methodological differences across studies.
Anna B. Szabo, Jonathan Curot, Fleur Gérard, Florence Rulquin, Rachel Debs, Claire Georges, Marie Denuelle, Amel Bouloufa, Béatrice Lemesle, Patrice Péran, Claire Thalamas, Emmanuel J. Barbeau, Jérémie Pariente, Lionel Dahan, Luc Valton   +14 more
wiley   +1 more source

Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease

Annals of Neurology, EarlyView.
Objective This 24‐month longitudinal study involving isolated rapid eye movement sleep behavior disorder (iRBD), early‐stage Parkinson's disease (PD), and matched healthy control subjects aimed to assess whether acoustic speech features from real‐world smartphone calls provide passive progressive biomarkers in synucleinopathies.
Michal Šimek, Tereza Tykalová, Michal Novotný, Vojtěch Illner, Tomáš Kouba, Martin Šubert, Pavel Sovka, Jan Švihlík, Evžen Růžička, Karel Šonka, Petr Dušek, Jan Rusz   +11 more
wiley   +1 more source

Current perpendicular to plane Giant Magnetoresistance (GMR) in laminated nanostructures

, 2004
We theoretically studied spin dependent electron transport perpendicular-to-plain (CPP) in magnetic laminated multilayered structures by using Kubo formalism.
A. Vedyayev, B. Dieny, Camblong, Eid, I. Zhukov, Kane, Valet, Vedyaev   +7 more
core   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Molecular Electroporation and the Transduction of Oligoarginines

, 2009
Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis.
Alberts B, Alberts B, Alberts B, Alberts B, Alberts B, Bevers E, Bulte J W, Cahill K, Datta K, Grandmaison P A, Hanke M, Harbour J W, Hosotani R, Kevin Cahill, Kuge O, Mai J C, Mendoza N, Vaara M, Vance J E, Voelker D, Vondrášek J   +20 more
core   +1 more source

Mechanistic aspects of CPP-mediated intracellular drug delivery: Relevance of CPP self-assembly

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
In recent years, cell-penetrating peptides have proven to be an efficient intracellular delivery system. The mechanism for CPP internalisation, which first involves interaction with the extracellular matrix, is followed in most cases by endocytosis and finally, depending on the type of endocytosis, an intracellular fate is reached.
Pujals, Sílvia, Fernández Carneado, Jimena, López Iglesias, Carmen, Kogan Bocian, Marcelo, Giralt, Ernest   +4 more
openaire   +2 more sources

Redox‐aktivierte Sonden für Hochkontrastige Live‐Bildgebung Postsynaptischer Neuronaler Gerüste

Angewandte Chemie, EarlyView.
Sylives sind modifizierte fluoreszierende Peptide für eine kontrastreiche Live‐Bildgebung inhibitorischer (Gephyrin) und exzitatorischer (PSD‐95) postsynaptischer Gerüststrukturen in nativen Neuronen. Eine saubere Markierung erfordert niedrige Sondenkonzentrationen im Nanomolarbereich, während die Aufnahme mikromolare Konzentrationen zellpenetrierender
Christiane Huhn, Clémence Mille, Sheng‐Yang Ho, Felix Lützenkirchen, Vladimir Khayenko, Melanie Hein, Christian Werner, Matthias Kneussel, Johannes W. Hell, Christian G. Specht, Hans M. Maric   +10 more
wiley   +1 more source

Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain

BMC Medicine
Background Chronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect a patient’s quality of life. Endometriosis is one cause of CPP, and alterations of the immune and microbiome profiles have been observed in patients with ...
Nicole Jimenez, Taylor Norton, Gurbeen Diadala, Emerald Bell, Michelle Valenti, Leslie V. Farland, Nichole Mahnert, Melissa M. Herbst-Kralovetz   +7 more
doaj   +1 more source

Redox‐Activated Probes Enable High‐Contrast Live Imaging of Native Postsynaptic Scaffolds

Angewandte Chemie International Edition, EarlyView.
Sylives are modified fluorescent peptides for high‐contrast live imaging of inhibitory (gephyrin) and excitatory (PSD‐95) postsynaptic scaffolds in native neurons. Clean labeling requires low nanomolar probe levels, whereas uptake needs micromolar cell‐penetrating peptide (CPP).
Christiane Huhn, Clémence Mille, Sheng‐Yang Ho, Felix Lützenkirchen, Vladimir Khayenko, Melanie Hein, Christian Werner, Matthias Kneussel, Johannes W. Hell, Christian G. Specht, Hans M. Maric   +10 more
wiley   +1 more source