Results 131 to 140 of about 1,093,718 (242)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The Impact of Educational LLM Agent Use on Teachers' Curriculum Content Creation: The Chain Mediating Role of School Support and Teacher Self-Efficacy. [PDF]
Behav Sci (Basel)Xu H, Chen M, Wang M, Lu J.
europepmc +1 more source
SRI analysis and asset management : independent or convergent ? : A field study on the French market [PDF]
This article analyzes how the actual and expected future activities of French Socially Responsible Investment (SRI) analysts may reveal a convergence process between SRI decisions and traditional financial investment decisions, that is a form of ...
Nicolas Mottis, Patricia Crifo
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Food for Cities. What roles for local governments in the Global South? [PDF]
, 2017 Bricas, Nicolas, Fages, Roxane
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Intermediate concepts in the generative dance between knowledge and knowing [PDF]
Nous nous proposons dans cet article de contribuer à éclairer l'interaction entre connaissance et savoir en action comme processus générateur de nouvelles connaissances.
Bernard Hubert, Régine Teulier
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Challenges, merits, and demerits of curriculum co-creation in a private sector dental college: an interventional phenomenological study from Pakistan. [PDF]
BMC Med EducZahra FT, Khan RA, Yasmin R.
europepmc +1 more source
"Memory and Mimesis" commence par une réflexion sur la relation entre l'esprit et la mémoire invoqué par un scénario quotidien de la vie d'un père jouant avec sa fille âgée d'un an dans un bistrot et extrapole, a partir de cette relation, une parallèle ...
Bardis, James
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source