Results 141 to 150 of about 230,446 (308)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Crack-closure and crack-growth measurements in surface-flawed titanium alloy Ti6Al-4V [PDF]

open access: yes
The crack-closure and crack-growth characteristics of the titanium alloy Ti-6Al-4V were determined experimentally on surface-flawed plate specimens. Under cyclic loading from zero to tension, cracks deeper than 1 mm opened at approximately 50 percent of ...
Elber, W.
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz   +3 more
wiley   +1 more source

Data base for crack growth properties of materials [PDF]

open access: yes
A computerized data base of crack growth properties of materials was developed for use in fracture control analysis of rocket engine components and other NASA space hardware.
Forman, Royce G.   +2 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Experimental Research on the Low-Cycle Fatigue Crack Growth Rate for a Stiffened Plate of EH36 Steel for Use in Ship Structures

open access: yesJournal of Marine Science and Engineering
This paper presents a straightforward approach for determining the low-cycle fatigue (LCF) crack propagation rate in stiffened plate structures containing cracks.
Qin Dong, Geng Xu, Wei Chen
doaj   +1 more source

Prediction of Fatigue Crack Growth Rate Based on Entropy Generation. [PDF]

open access: yesEntropy (Basel), 2019
Idris R   +3 more
europepmc   +1 more source

Growth of surface and corner cracks in beta-processed and mill-annealed Ti-6Al-4V [PDF]

open access: yes
Empirical stress-intensity expressions were developed to relate the growth of cracks from corner flaws to the growth of cracks from surface flaws. An experimental program using beta-processed Ti-6Al-4V verified these expressions for stress ratios, R ...
Bell, P. D.
core   +1 more source

Effect of Microstructure on Time Dependent Fatigue Crack Growth Behavior In a P/M Turbine Disk Alloy [PDF]

open access: yes, 2008
A study was conducted to determine the processes which govern hold time crack growth behavior in the LSHR disk P/M superalloy. Nineteen different heat treatments of this alloy were evaluated by systematically controlling the cooling rate from the ...
Bonacuse, P.   +3 more
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini   +28 more
wiley   +1 more source

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