Results 41 to 50 of about 18,112 (283)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Quantifying nonlinear fracture parameters in bituminous SCB specimens: A compliance-based approach

Case Studies in Construction Materials
Bituminous mixtures containing various defects, such as cracks and voids, exhibit ductile behavior in hot environments and brittle behavior in cold environments.
Ragip Ince, Erkut Yalcin, Mehmet Yilmaz
doaj   +1 more source

Investigation on the properties of concrete with recycled polyethylene terephthalate (PET) granules as fine aggregate replacement

Case Studies in Construction Materials, 2022
Waste management is an area of significant global concern. The reuse of waste materials (such as: plastics, glass, wood, etc.) in concrete manufacturing has been studied for potential cost savings, improvements in quality, and reduction of environmental ...
Mohammad Eyni Kangavar, Weena Lokuge, Allan Manalo, Warna Karunasena, Mariaenrica Frigione   +4 more
doaj   +1 more source

Lamb wave near field enhancements for surface breaking defects in plates [PDF]

, 2012
Near field surface wave ultrasonic enhancements have previously been used to detect surface breaking defects in thick samples using Rayleigh waves. Here, we present analogous surface wave enhancements for Lamb waves propagating in plates.
Clough, A. R., Edwards, R. S. (Rachel S.)   +1 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Experimental study on fracture behavior of pre-notched mortar beams using ESPI technique [PDF]

, 2011
Electronic Speckle Pattern Interferometry (ESPI) technique is of high sensitivity and can provide full-field surface deformation. This paper introduces the application of ESPI technique to measure the surface deformation of pre-notched mortar beams in ...
Chen, H, Su, RKL
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Applicability of CMOD to Obtain the Actual Fracture Toughness of Rightly-Cracked Fibrous Concrete Beams

Buildings, 2023
Unfortunately, most of the previous work studying the fracture toughness of fibrous composites has deliberately ignored bridging the fiber onto the pre-crack/notch surfaces by creating such a crack as a through-thickness crack (TTC).
Mahmoud A. Abdallah, Ahmed A. Elakhras, Ramy M. Reda, Hossam El-Din M. Sallam, Mohamed Moawad   +4 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source