Results 41 to 50 of about 41,875 (254)

Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes

Diabetes, Metabolic Syndrome and Obesity, 2022
Huiqing Hu,1 Chuan Wang,1– 4 Kai Liang,1– 4 Qin He,1 Jia Song,1 Xinghong Guo,1 Xinguo Hou,1– 4 Li Chen,1– 4 Fei Yan1– 4 1Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic of ...
Huiqing Hu, Wang C, Liang K, He Q, Song J, Guo X, Hou X, Chen L, Yan F   +8 more
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Breathing And Stretching Exercises Affect The Decrease in The Intensity of Leg Cramp Pain

Jurnal Ilmu dan Teknologi Kesehatan, 2021
Leg cramps are a common side effect of intradialysis CKD patients. Preventing intradialysis cramping pain can improve quality of life. Breathing and stretching exercises are non-pharmacological treatments for cramping pain.
Achwan Achwan, Abdurahman B.B. Laksono
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Prevalence of Intradialytic Muscle Cramps and Quality of Life in Haemodialysis Patients

Journal of Bahria University Medical and Dental College
Objective: The aim of this study was to find out prevalence of intradialytic muscle cramps and quality of life in hemodialysis patients.   Study design and settings: This was a cross-sectional study conducted in three different hospitals in ...
Somiya Naz, Mubashar Nazar, Waqas Khalid, Laraib Akhtar Malik, Abeera Tahir, Muhammad Mujtaba Ur Rehman   +5 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A Higher Concentration of Dialysate Magnesium to Reduce the Frequency of Muscle Cramps: A Narrative Review

Canadian Journal of Kidney Health and Disease, 2020
Purpose of review: Strategies to mitigate muscle cramps are a top research priority for patients receiving hemodialysis. As hypomagnesemia is a possible risk factor for cramping, we reviewed the literature to better understand the physiology of cramping ...
Akshay Varghese, Eduardo Lacson, Jessica M. Sontrop, Rey R. Acedillo, Ahmed A. Al-Jaishi, Sierra Anderson, Amit Bagga, Katie L. Bain, Laura L. Bennett, Clara Bohm, Pierre A. Brown, Christopher T. Chan, Brenden Cote, Varun Dev, Bonnie Field, Claire Harris, Shasikara Kalatharan, Mercedeh Kiaii, Amber O. Molnar, Matthew J. Oliver, Malvinder S. Parmar, Melissa Schorr, Nikhil Shah, Samuel A. Silver, D. Michael Smith, Manish M. Sood, Irina St. Louis, Karthik K. Tennankore, Stephanie Thompson, Marcello Tonelli, Hans Vorster, Blair Waldvogel, James Zacharias, Amit X. Garg,   +34 more
doaj   +1 more source