Results 81 to 90 of about 496,309 (246)

Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration.

PLoS ONE, 2014
Therapeutic irradiation is commonly used to treat primary or metastatic central nervous system tumors. It is believed that activation of neuroinflammatory signaling pathways contributes to the development of common adverse effects, which may ultimately ...
Josh M Morganti, Timothy D Jopson, Sharon Liu, Nalin Gupta, Susanna Rosi   +4 more
doaj   +1 more source

Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy.

, 1994
PURPOSE To examine behavioral dimensions of treatment outcomes for patients receiving cranial irradiation. Radiation encephalopathy is one of these and refers to significant cognitive and emotional dysfunction following radiation therapy to the brain ...
J R Crossen, E Glatstein, D Garwood, E A Neuwelt   +3 more
core   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

A practical technique to avoid the hippocampus in prophylactic cranial irradiation for lung cancer.

, 2012
A practical technique is presented to deliver hippocampus avoiding prophylactic cranial irradiation for lung cancer patients, using two lateral fields.
van Vliet-Vroegindeweij, Corine, Lamers, Emmy, Belderbos, José, van Kesteren, Zdenko, van Herk, Marcel, De Ruysscher, Dirk, Van Herk, Marcel; id_orcid, Olszewska, Agnieszka, Damen, Eugène   +8 more
core   +1 more source

Spinal Involvement in Charge Syndrome: Implications for Management

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT CHARGE syndrome (OMIM #214800) is an autosomal dominant disorder caused by mutations in the CHD7 gene in most cases. Although originally defined by the CHARGE acronym (coloboma, heart defects, choanal atresia, growth restriction, genital hypoplasia, and ear anomalies), the recognized phenotype has expanded considerably to include highly ...
Adriana Gomes, Álvaro Martín‐Rodríguez, Miguel del Campo Casanelles, Marilyn C. Jones, Daniela Carvalho, Lynne M. Bird   +5 more
wiley   +1 more source

Cranial Irradiation Leads to Acute and Long-Lasting Deficits in Proliferating Cell Populations in the Adult Brain

, 2021
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Translational Biomedical Sciences, 2019.Cranial radiotherapy is effective for treating brain tumors due to its anti-proliferative effects on cancer cells.
Olschowka, John A., Belcher, Elizabeth Kathleen, O'Banion, M. Kerry   +2 more
core  

Prenatal Presentation of RMRP‐Related Skeletal Dysplasia: Clinical and Genomic Expansion

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT The RNA subunit of the mitochondrial RNA processing endoribonuclease complex is encoded by RMRP. Biallelic variants in RMRP are known for anauxetic dysplasia 1 (AD), cartilage‐hair hypoplasia (CHH), and metaphyseal dysplasia without hypotrichosis.
Radhakrishnan Periyasamy, Pascal Joset, H. E. Veenstra‐Knol, Nicole Corsten‐Janssen, Tuula Rinne, Irene Valenzuela, Marta Codina‐Solà, Carlota Rodó, Marjolaine Willems, Constance Wells, Renaud Touraine, Maayke de Koning, Gijs Santen, Iris Hollink, André Travessa, Alessandro Mauro Spinelli, Paolo Peruzzo, Moneef Shoukier, Roland Axt‐Fliedner, Thomas Menter, Gwendolin Manegold‐Brauer, Isabel Filges   +21 more
wiley   +1 more source

Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments

Advanced Biomedical Research, 2012
Background: Neurocognitive deficits and decrease in intelligence quotient (IQ) is one of the complication of prophylactic central nervous system (CNS) treatment in acute lymphoblastic leukemia (ALL) patients. In this study, we compare the IQ in survivors
Reisi Nahid, Khalilian Leila
doaj   +1 more source

Cranial Irradiation-Mediated Dendritic Spine Loss Is Microglial Complement Receptor 3-Dependent, SexSpecific, and Associated with Cognitive Impairment

, 2021
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Neuroscience Graduate Program, 2020.Cranial irradiation is the main therapeutic treatment for primary and metastatic malignancies in the brain.
Olschowka, John A., Hinkle, Joshua, O'Banion, M. Kerry   +2 more
core  

The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates

The Anatomical Record, EarlyView.
Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
wiley   +1 more source