Results 181 to 190 of about 59,066 (338)

Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH‐wildtype

open access: yesBrain Pathology, EarlyView.
The molecular profile of adult primary leptomeningeal gliomatosis closely aligned with that of adult‐type glioblastoma, IDH‐wildtype, CNS WHO grade 4. Abstract Adult primary leptomeningeal gliomatosis (PLG) is a rare, rapidly progressive and fatal disease characterized by prominent leptomeningeal infiltration by a glial tumor without an identifiable ...
Yi Zhu   +14 more
wiley   +1 more source

Brain‐derived textiloma post glioblastoma resection and application of oxidized regenerated cellulose: A pilot, bedside‐to‐bench, translational study

open access: yesBrain Pathology, EarlyView.
Following glioblastoma resection with oxidized regenerated cellulose application, a patient developed an intracranial mass histopathologically linked to a microglial foreign body reaction in response to the hemostatic material. Mechanistic studies characterized the cytokine response and reduced viability of microglia, supporting the inflammatory ...
Joshua A. Kra   +8 more
wiley   +1 more source

A Multicenter Phase II Trial of Nimustine Hydrochloride Administered via Convection‐Enhanced Delivery in Children With DIPG

open access: yesCancer Science, EarlyView.
The efficacy of the CED of nimustine hydrochloride in pediatric DIPG was evaluated. One‐year survival rate from the start of radiotherapy was 60%. The treatment strategy demonstrated potential efficacy. ABSTRACT Diffuse intrinsic pontine glioma (DIPG) is a very challenging‐to‐treat pediatric malignant tumor, with a median survival time of < 12 months ...
Ryuta Saito   +13 more
wiley   +1 more source

CDK13‐Related Disorder: Novel Insights From A Series of 27 Cases and Recommendations for Clinical Management

open access: yesClinical Genetics, EarlyView.
This report described 27 novel subject with CDK13‐related disorders. Collecting the clinical and radiological data, we better define the phenotypic spectrum of this condition and we suggest a comprehensive clinical management. ABSTRACT In 2016, Sifrim and colleagues described the first group of patients carrying heterozygous pathogenic variants in ...
Gianluca Contrò   +57 more
wiley   +1 more source

Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants

open access: yesDevelopment, Growth &Differentiation, Volume 67, Issue 3, Page 136-148, April 2025.
Some transcription factors exhibit chromosomal localization during M‐phase and play an important role in the rapid re‐activation of target genes in early G1‐phase. In this study, we assessed the chromosomal localization of Paired‐like homeodomain 2B (PHOX2B) and its disease‐associated mutants, and found that disease‐associated PHOX2B mutants exhibited ...
Yuki Sato   +8 more
wiley   +1 more source

Neurodevelopmental outcome of perinatal intracranial haemorrhage in patients born at term: A prospective study

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Aim To assess the neurological and neurodevelopmental outcome of infants born at term with perinatal intracranial haemorrhage (pICH) and examine the clinical and neuroimaging associations. Method A prospective, consecutive, single‐center observational study of longitudinally followed children with pICH identified in the fetal or neonatal ...
Stephanie Libzon   +9 more
wiley   +1 more source

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