Results 31 to 40 of about 505,925 (272)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Isolated Post-Traumatic Syringobulbia; Case Report and Review of the Literature [PDF]

Bulletin of Emergency and Trauma, 2014
Syringobulbiais very rare condition defined as slit-like fluid cavity in the brain stem. Several conditions have been reported to be associated with syringobulbia including neoplasms, spinal cord traumas or lesions such as tethered cord, hind-brain ...
Mousa Taghipour, Nima Derakhshan, Fariborz Ghaffarpasand   +2 more
doaj   +2 more sources

Electrical stimulation decreases neuralgic pain after trigeminal deafferentation [PDF]

, 2008
Trigeminal nerve activity mediates head pain after cranial injuries, and also contributes to idiopathic syndromes such as cluster headache and trigeminal neuralgia. Nevertheless, chronic facial pain sometimes develops after lesion of the trigeminal nerve.
Treleaven-Hassard, S., Drummond, P.D.
core  

Sensory pathways in the human embryonic spinal accessory nerve with special reference to the associated lower cranial nerve ganglia

, 2014
Background and purpose Muscles supplied by the spinal accessory nerve are particularly prone to the development of trigger points characteristic of myofascial pain.
Jang, Hyung Suk, Murakami, Gen, Cheong, Jin Sung, Cho, Kwang Ho, Rodríguez Vázquez, José Francisco, Abe, Hiroshi   +5 more
core   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Paragangliomas da Cabeça e Pescoço: A Experiência de um Centro Oncológico do Sul da Europa

Acta Médica Portuguesa, 2022
Introduction: Paragangliomas are usually benign slow-growing tumors, but they are locally invasive and can cause significant morbidity. The aim of this study was to characterize the presenting symptoms, secretory status, genetics, imaging features ...
Luís Castelhano, Filipe Correia, Sara Donato, Lígia Ferreira, Pedro Montalvão, Miguel Magalhães   +5 more
doaj   +1 more source

COVID-19 associated cranial nerve neuropathy: A systematic review [PDF]

, 2022
The involvement of cranial nerves is being increasingly recognised in COVID-19. This review aims to summarize and discuss the recent advances concerning the clinical presentation, pathophysiology, diagnosis, treatment, and outcomes of SARS-CoV-2 ...
Josef Finsterer, Fiorini, Ana, Ana Fiorini, Finsterer, Josef, Scorza, Fulvio Alexandre, Fulvio Alexandre Scorza, Carla Scorza, Scorza, Carla   +7 more
core   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

A metric study of three types of artificial cranial modification from north-central Peru

, 2010
Artificial cranial modification (ACM) involves the alteration of cranial vault shape by cultural means, and is performed during infancy while the cranial bones remain soft and malleable.
Zakrzewski, Sonia, Stock, Jay T., Mirazon Lahr, Marta, Pomeroy, Emma   +3 more
core   +1 more source