Results 161 to 170 of about 33,907 (296)

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki   +4 more
wiley   +1 more source

Rescue Therapy With Quad Zygoma After Failure of Full‐Arch Implant Rehabilitation: A Retrospective Study With a Mean Follow‐Up of 8 Years

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To evaluate the long‐term clinical outcomes of quad zygomatic implants (ZIs) as a rescue therapy for patients with failed full‐arch implant rehabilitation in the maxilla due to advanced peri‐implantitis. Material and Methods This was a retrospective cohort study of all patients treated with the Quad Zygoma Protocol. Primary outcomes
Shengchi Fan   +4 more
wiley   +1 more source

Kdf1 Regulates Molar Cusp Morphogenesis via the PI3K/AKT/mTOR Signalling Axis

open access: yesCell Proliferation, EarlyView.
Epithelial Kdf1 knockout disrupts molar cusp morphogenesis by promoting inner enamel epithelium proliferation and invagination via PI3K/AKT/mTOR signalling. ABSTRACT Keratinocyte differentiation factor 1 (Kdf1) reportedly plays a significant role in enamel formation.
Jiayu Wang   +9 more
wiley   +1 more source

PLGA-based control release of Noggin blocks the premature fusion of cranial sutures caused by retinoic acid. [PDF]

open access: yesAppl Microbiol Biotechnol, 2019
Wang W   +8 more
europepmc   +1 more source

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

open access: yesCell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu   +10 more
wiley   +1 more source

Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis. [PDF]

open access: yesBBA Clin, 2016
Katsianou MA   +3 more
europepmc   +1 more source

Successful repair of a carpal sheath synovial hernia using a polypropylene mesh

open access: yesEquine Veterinary Education, EarlyView.
Summary A cob‐cross mare presented with a carpal sheath synovial hernia on the distolateral antebrachium following carpal sheath tenoscopy to treat a radial physeal exostosis and deep digital flexor tendon injury. The presumed source of pain was the weakened skin over the hernia as the intrathecal pathology identified at the initial tenoscopy had ...
S. R. L. Neild   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy