Results 41 to 50 of about 33,542 (296)

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

Clinical applications of molecular basis for Craniosynostosis. A narrative review.

Journal of Oral Research, 2016
Cranial sutures are specialized structures composed of the sutural mesenchyme, the overlying scalp, the dura and osteogenic fronts. Each one of these structures express important proteins for osteogenic maturation, membranous ossification of skull bones,
Saúl Ernesto Cifuentes-Mendiola, Isaac Obed Pérez-Martínez, Ángel Enrique Muñoz-Saavedra   +2 more
doaj   +1 more source

A computer-based simulation of vacuum extraction during childbirth [PDF]

, 2014
Vacuum extraction is an instrumental method used in obstetrics when childbirth labour fails to progress. The instrument used during vacuum extraction is the ventouse. It comprises of a suction cup attached to the fetal scalp through a vacuum, and a chord
Audinis, Vilius, Gerikhanov, Zelimkhan, Lapeer, Rudy   +2 more
core  

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Age Estimation by Machine Learning and CT-Multiplanar Reformation of Cranial Sutures in Northern Chinese Han Adults [PDF]

Fayixue Zazhi
Objective To establish age estimation models of northern Chinese Han adults using cranial suture images obtained by CT and multiplanar reformation （MPR）, and to explore the applicability of cranial suture closure rule in age estimation of northern ...
Xuan WEI, Yu-shan CHEN, Jie DING, Chang-xing SONG, Jun-jing WANG, Zhao PENG, Zhen-hua DENG, Xu YI, Fei FAN
doaj   +1 more source

The Accuracy of Age Estimation Using Transition Analysis in the Hamann-Todd Collection [PDF]

, 2020
Trying to reconstruct the demographic parameters of past populations using skeletal data is challenging for several reasons. First, skeletal traits are proxy to biological age, which does not always reflect chronological age.
Simon, Allyson
core  

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance [PDF]

, 2015
Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investigate
Barak, Benazzi, Berthaume, Bright, Bright, Chamoli, Cox, Curtis, Daegling, Dechow, Fagan, Fitton, Fitton, Gross, Gröning, Gröning, Gröning, Gröning, Horgan, Jansen van Rensburg, Keyak, Kupczik, Kupczik, Lengsfeld, Lieberman, Liu, Marinescu, McElhaney, Menegaz, Meredith, Milne, Misch, Moazen, Moss, O'Higgins, O'Higgins, O'Higgins, Olesiak, Peterson, Rayfield, Renders, Ross, Schwartz-Dabney, Smith, Smith, Strait, Strait, Szwedowski, Toro-Ibacache, Truesdell, Turner-Walker, Wang, Wood, Wroe, Yang, Yang   +55 more
core   +2 more sources

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Nonsyndromic multisuture craniosynostosis with unilateral coronal and lambdoid suture involvement

Interdisciplinary Neurosurgery
Background: Craniosynostosis results from the premature fusion of cranial sutures and represents a severe congenital craniofacial disorder. It may occur as part of a recognized genetic syndrome or as an isolated condition.
Vázquez Flores Jesús de Marco, Ramos Fraga Bernardo, Ferreira Ascencio Frida Leslie, López Hernández Paul André   +3 more
doaj   +1 more source