Results 31 to 40 of about 81,502 (284)

Identification and Prioritization of Hazardous Road Locations by Segmentation and Data Envelopment Analysis Approach

Promet (Zagreb), 2013
The aim of the present study is the representation of a method to identify and prioritize accident-prone sections (APSs) based upon efficiency concept to emphasize accidents with regard to traffic, geometric and environmental circumstances of road which ...
Aliasghar Sadeghi, Esmaeel Ayati, Mohammadali Pirayesh Neghab   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

General Cognitive Impairment as a Risk Factor for Motor Vehicle Collision Involvement: A Prospective Population-Based Study

Geriatrics, 2018
This study examined whether cognitive impairment and decline as assessed by a brief mental status screening test is associated with future crash risk in a cohort of older drivers.
Carrie Huisingh, Cynthia Owsley, Virginia G. Wadley, Emily B. Levitan, Marguerite R. Irvin, Paul MacLennan, Gerald McGwin   +6 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Geometric Optimization and Mechanical Performance Enhancement of Auxetic Structures for High‐Impact Applications Through Fused Deposition Modeling

Advanced Engineering Materials, EarlyView.
This study explores the mechanical performance of three auxetic structures, identifying a re‐entrant‐star hybrid as the most effective for impact absorption. Finite element simulations and experiments demonstrate significant gains in energy absorption and flexural strength after geometric optimization. This study investigates the mechanical performance
Malik Hassan, Manjusri Misra, Alexander Bardelcik, Stefano Gregori, Amar K. Mohanty   +4 more
wiley   +1 more source

Acquiring intangible remittances for Ukraine by female war migrants: is there a ‘cumulative advantage effect’?

Comparative Migration Studies
This article—part of the Special Issue on “(In)tangible Remittances and Inequalities”—investigates the acquisition of social remittances by Ukrainian female war migrants in Poland.
Izabela Grabowska
doaj   +1 more source

X‐Ray Tomography Analysis of Damage Mechanisms in Metal Matrix Syntactic Foams During Compression

Advanced Engineering Materials, EarlyView.
In situ synchrotron X‐ray tomography is used to investigate the internal damage mechanisms of AlSi12 metal matrix syntactic foam with ceramic hollow spheres during compressive loading. It is concluded that a homogeneous distribution of the second‐phase filler material results in a sequential collapse in a localized region; this leads to controlled and ...
Indrajeet Tambe, János Endre Maróti, Imre Norbert Orbulov, Zoltan Hegedűs, Markus Ziehmer, Carl E. Krill III, Håkan Hallberg, Pär A. T. Olsson, Johan Hektor   +8 more
wiley   +1 more source

A radiographic and physical analysis of factors affecting seat belt position in sitting car seat

Scientific Reports, 2022
The characteristic subcutaneous hemorrhage along the seat belt in motor vehicle accidents is called the seat belt sign (SBS). The risk of organ injuries is especially high when abdominal SBS is located above the anterior superior iliac spine (ASIS).
Hiroki Yamagata, Norihiro Nishida, Tomohiro Izumiyama, Ryusuke Asahi, Masahiro Koike, Atsushi Mihara, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Shigeru Sugimoto, Masanobu Fukushima, Takashi Sakai   +11 more
doaj   +1 more source