Results 51 to 60 of about 99,827 (273)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Explaining Crash Predictions on Multivariate Time Series Data

, 2022
In Assicurazioni Generali, an automatic decision-making model is used to check real-time multivariate time series and alert if a car crash happened. In such a way, a Generali operator can call the customer to provide first assistance. The high sensitivity of the model used, combined with the fact that the model is not interpretable, might cause the ...
Spinnato F., Guidotti R., Nanni M., Maccagnola D., Paciello G., Farina A. B.   +5 more
openaire   +3 more sources

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

INVESTIGATION OF ROADWAY GEOMETRIC AND TRAFFIC FLOW FACTORS FOR VEHICLE CRASHES USING SPATIOTEMPORAL INTERACTION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
Traffic safety is a major concern in the transportation industry due to immense monetary and emotional burden caused by crashes of various severity levels, especially the injury and fatality ones.
G. Gill, T. Sakrani, W. Cheng, J. Zhou
doaj   +1 more source

Risk Adjustment In Neurocritical care (RAIN)--prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study. [PDF]

, 2013
OBJECTIVES: To validate risk prediction models for acute traumatic brain injury (TBI) and to use the best model to evaluate the optimum location and comparative costs of neurocritical care in the NHS. DESIGN: Cohort study.
Gomes, M, Grieve, R, Griggs, KA, Harrison, DA, Harvey, SE, Hutchinson, PJA, Lecky, FE, Menon, DK, Prabhu, G, Rowan, KM, Sadique, MZ, Smith, M, Walmsley, E, Yeoman, P   +13 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Does the bond-stock earning yield differential model predict equity market corrections better than high P/E models? [PDF]

, 2014
In this paper, we extend the literature on crash prediction models in three main respects. First, we relate explicitly crash prediction measures and asset pricing models.
Lleo, Sebastien, Ziemba, William T.
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Can analysts predict rallies better than crashes? [PDF]

Finance Research Letters, 2014
We use the copula approach to study the structure of dependence between sell-side analysts' consensus recommendations and subsequent security returns, with a focus on asymmetric tail dependence. We match monthly vintages of I/B/E/S recommendations for the period January to December 2011 with excess security returns during six months following ...
openaire   +3 more sources

Adaptive Twisting Metamaterials

Advanced Materials, EarlyView.
This work introduces torque‐controlled twisting metamaterials as a transformative platform for adaptive crashworthiness. By combining multiscale predictive modeling with experimental validation on additively manufactured gyroids, it demonstrates tunable stiffness, collapse stress, and energy absorption.
Mattia Utzeri, Maria L. Gatto, Edoardo Mancini, Donato Orlandi, Daniele Cortis, Marco Sasso, Shanmugam Kumar   +6 more
wiley   +1 more source