Results 81 to 90 of about 99,827 (273)

Learning to Fly by Crashing

, 2017
How do you learn to navigate an Unmanned Aerial Vehicle (UAV) and avoid obstacles? One approach is to use a small dataset collected by human experts: however, high capacity learning algorithms tend to overfit when trained with little data. An alternative
Gandhi, Dhiraj, Gupta, Abhinav, Pinto, Lerrel   +2 more
core   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

DEVELOPMENT OF AN INFRASTRUCTURE COEFFICIENT BY AN ANALYTIC HIERARCHY PROCESS AND ITS RELATIONSHIP TO SAFETY

IATSS Research, 2007
The study has four main objectives: (1) to test the correlation between different infrastructure characteristics and crash-rates, and trends; (2) to develop an Infrastructure Coefficient (IC) that represents the overall infrastructure characteristics of ...
Haneen FARAH
doaj   +1 more source

The Impacts of Using a Safety Compliance Standard in Highway Design [PDF]

, 1999
Dr. Ossenbruggen introduces an algorithmic method to objectively test and evaluate safety in the highway design ...
Ossenbruggen, Paul J.
core   +2 more sources

Predictability of catastrophic events: material rupture, earthquakes, turbulence, financial crashes and human birth

, 2001
We propose that catastrophic events are "outliers" with statistically different properties than the rest of the population and result from mechanisms involving amplifying critical cascades.
Broecker, D. Sornette, Geller, Gould, Jones, Lamaign  re, McWilliams, Papiernik, Sornette, Sornette   +9 more
core   +2 more sources

Scalable Upcycling of Spent Lithium‐Ion Battery Anodic Graphite to Electronic‐Grade Graphene

Advanced Science, EarlyView.
Graphite anodes from spent lithium‐ion batteries are upcycled into electronic‐grade graphene nanoplatelets for highly conductive screen printing inks (> 104 S m−1). Screen‐printed micro‐supercapacitors confirm the utility of the upcycled graphene (1.78 mF/cm2 capacitance for > 10 000 cycles). Life cycle assessment and techno‐economic analysis highlight
Janan Hui, Jenna N. Trost, Wesley Y. Chen, Maryam Khalaj, Lindsay E. Chaney, Peyton Melin, Albert L. Lipson, Jennifer B. Dunn, Mark C. Hersam   +8 more
wiley   +1 more source

The 1929 stock market: Irving Fisher was right [PDF]

Many stock market analysts think that in 1929, at the time of the crash, stocks were overvalued. Irving Fisher argued just before the crash that fundamentals were strong and the stock market was undervalued.
Edward C. Prescott, Ellen R. McGrattan
core  

A New Model of Crash Severities Reportable to the MCMIS Crash File [PDF]

, 2010
The Motor Carrier Management Information system (MCMIS) Crash file has been developed by the Federal Motor Carrier Safety Administration (FMCSA) to serve as a census file of trucks and buses involved in traffic crashes meeting a specific crash severity ...
Blower, Daniel Frederick, Green, Paul E.
core