Results 161 to 170 of about 429,003 (305)

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

Outcomes of 'in-house' genetic testing within a specialist hereditary colorectal cancer registry. [PDF]

Colorectal Dis
Srisuttayasathien M, Cuthill V, Hawkins M, Sinha A, Clark S, Latchford A, Monahan KJ.   +6 more
europepmc   +1 more source

Australian Sheep Industry CRC: Economic Evaluations of Scientific Research Programs [PDF]

By the end of its seven-year term in 2007-08, the Australian Sheep Industry CRC (Sheep CRC) will have received total funds of about $90 million, that comprises Commonwealth and industry funding of $30 million, and in-kind contributions valued at $60 ...
Griffith, Garry R., Vere, David T., Silvester, Luke T.   +2 more
core  

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

A Generalizable Multimodal Model for Treatment‐Stratified Risk and Survival Assessment under Real‐World Constraints: A Multi‐Center Study of Colorectal Cancer

Advanced Science, EarlyView.
DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao, Zheyi Ji, Chang He, Jiying Wang, Xiaoming Luo, Junyi Liu, Xiaohu Jing, Fang Yan, Yirong Chen, Linhao Qu, Sen Yang, Le Lu, Yuming Jiang, Xiyue Wang, Chengyun Dou, Junhan Zhao   +15 more
wiley   +1 more source

Inverse Association Between Regional Availability of Board-Certified Fellows of the Japan Gastroenterological Endoscopy Society and Colorectal Cancer Mortality in Japan: An Ecological Analysis. [PDF]

JGH Open
Inoki K, Rahman M, Mizuno S, Suzuki N, Nakatani S, Kikuchi K, Katagiri A, Yoshida H, Kakushima N.   +8 more
europepmc   +1 more source

Lipid Accumulation Promotes Tumorigenic Behaviour of Colorectal Cancer Cells. [PDF]

J Cell Mol Med
Itzenhäuser T, Schildt FS, Jochem S, Sommer J, Stürzl M, Naschberger E, Boßerhoff AK, Hellerbrand C.   +7 more
europepmc   +1 more source

Nonlinear Ion‐Specific Control of Underwater Adhesion by Bottlebrush Polymer Interfaces

Advanced Science, EarlyView.
The efficiency of underwater adhesion is modulated by ion‐specific effects. Strongly hydrated Na+ remains separated from the mica surface by its hydration shell, preserving access to binding sites, whereas weakly hydrated K+ can partially dehydrate and occupy ditrigonal cavities.
Chang‐Sheng Wang, Hui Guo, Hu Zhang, Duy Anh Pham, Nahid Hassanpour, Wojciech Raj, Qiang Peng, Justine Saber, Tzu‐Hsuan Huang, Florina G. Halmac, Xavier Banquy   +10 more
wiley   +1 more source

Effectiveness and Safety of Colorectal Cancer Screening Via Fecal Occult Blood Testing: A Systematic Review and Meta-Analysis. [PDF]

J Gastrointest Cancer
Frankenfeld MCJ, Patah GC, Soares LT, Silva SN, Romeiro FG, Nogueira VDSN.   +5 more
europepmc   +1 more source