Results 261 to 270 of about 943,536 (329)

CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis. [PDF]

Nat Genet
Chan ICC, Zhang P, Pan X, Castro C, Fox N, Lewis AM, Weis K, Cuibus A, Tittley S, Petrone G, Beeler JS, Tran D, Mustion G, Fronick C, Stopsack KH, Cruchaga C, Abdel-Wahab O, Bolton KL.   +17 more
europepmc   +1 more source

フランスにおける独立行政機関(AAI)の創設 : CREを例に

, 2013
恭明 半田
openalex   +1 more source

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

The ALX1 transcription factor acts in the early cranial mesoderm to specify extraocular muscle formation.

Dis Model Mech
Iyyanar PPR, Adhikari N, Lan Y, Jiang R.
europepmc   +1 more source

<i>Fgf8/18</i> antagonizes <i>Shh</i> expression in lingual ventral-dorsal patterning. [PDF]

Front Cell Dev Biol
Yang S, Xue J, Liu H, Zhou N, Feng H, Li N, Liu B, Zhu L, Xiao J, Liu C.   +9 more
europepmc   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Generation of a Novel Col8a2^P2A-CreERT2 Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation. [PDF]

Genesis
Yuan Y, Holt J, Lorry S, Wang YC, Hu YC, Ma Z, Kaufman A, Kao W, Ogando DG, Liu CY.   +9 more
europepmc   +1 more source

A prerrogativa do direito na Conferência Regional de Educação Superior da América Latina e do Caribe (CRES) 2018

, 2018
Egeslaine de Nez, Warley Carlos de Souza
openalex   +2 more sources

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Generation of Mice Harboring Bicc1 Conditional Null Alleles. [PDF]

Genesis
Liu CF, Leon S, Herrig I, Wessely O, Tang WHW.   +4 more
europepmc   +1 more source