Results 111 to 120 of about 1,019,575 (429)

The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]

open access: yes, 2015
The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio   +16 more
core   +1 more source

Prognostic Impact of Bone Mineral Density Reduction During Neoadjuvant Chemotherapy (NAC) in Patients Undergoing NAC Followed by Esophagectomy for Esophageal Cancer

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
The association between BMD reduction during NAC and the worse prognosis remains unknown, although NAC followed by esophagectomy is a standard treatment for advanced ESCC. This study appeared that BMD massive reduction was an independent prognostic factor on OS (HR, 3.30; 95% confidence interval [CI], 1.69–6.55) and RFS (HR, 2.08; 95% CI, 1.19–3.63 ...
Kazuhide Sato   +11 more
wiley   +1 more source

Carrier detection in Duchenne muscular dystrophy [PDF]

open access: yes, 1984
The identification of apparently healthy carriers of the lethal, X- linked gene for Duchenne muscular dystrophy (DMD) is of importance for genetic counselling purposes.
Freeman, Lesley Carolyn
core   +1 more source

Immune myopathies with perimysial pathology: Clinical and laboratory features [PDF]

open access: yes, 2018
ObjectiveImmune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium.
Bucelli, Robert C, Pestronk, Alan
core   +2 more sources

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao   +6 more
wiley   +1 more source

Creatine Kinase Activity and Malondialdehyde in the Seminal Plasma of Normospermic Infertile Males

open access: yesمجلة كلية الطب, 2009
Background: Normospermia might be a major problem to the doctor and the infertile couple because the male seminal sample has an accepted seminal parameters during the routine seminal examination and the female partner will be claimed for the infertility ...
Ghassan T. Alani, Hedef D. El Yaseen
doaj   +1 more source

Ethnic Differences in Tissue Creatine Kinase Activity: An Observational Study

open access: yesPLoS ONE, 2012
Background Serum creatine kinase (CK) levels are reported to be around 70% higher in healthy black people, as compared to white people (median value 88 IU/L in white vs 149 IU/L in black people).
L. Brewster   +4 more
semanticscholar   +1 more source

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin   +9 more
wiley   +1 more source

Reduced exercise capacity is associated with left ventricular systolic dysfunction in long‐term survivors of allogeneic hematopoietic stem‐cell transplantation

open access: yesJournal of Clinical Ultrasound, Volume 51, Issue 1, Page 5-15, January 2023., 2023
Exercise intolerance is a common complication in long‐term survivors of allogeneic hematopoietic stem‐cell transplantation. In this study, we found reduced oxygen uptake (VO2peak) by cardio‐pulmonary exercise tests to be associated with left ventricular systolic dysfunction by echocardiography.
Richard John Massey   +8 more
wiley   +1 more source

Overview of Current Type I/II Kinase Inhibitors [PDF]

open access: yesarXiv, 2018
Research on kinase-targeting drugs has made great strides over the last 30 years and is attracting greater attention for the treatment of yet more kinase-related diseases. Currently, 42 kinase drugs have been approved by the FDA, most of which (39) are Type I/II inhibitors.
arxiv  

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