Results 181 to 190 of about 960,906 (340)

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

open access: yesAdvanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong   +16 more
wiley   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

open access: yesAdvanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu   +13 more
wiley   +1 more source

Detection of Nephropathy in Prehypertensive Subjects

open access: yesJournal of Rawalpindi Medical College, 2014
Background: To study the trend in levels of serum creatinine in prehypertensive people for detection of renal dysfunction. Methods: In this descriptive study a total of 90 apparently healthy subjects with age being 30-55 years and without any other ...
Usman Wali
doaj  

Nanosensitizer for Cancer Radioimmunotherapy via Anti‐IL‐35 Blockade Boosted Innate Immunity Activation

open access: yesAdvanced Science, EarlyView.
Zheng et al. designed a tumor microenvironment (TME)‐responsive nanosystem, HmBMH@MSA‐2. It targets tumors, releases MSA‐2 and Mn ions in high glutathione (GSH) conditions, achieving STING agonist delivery and MRI. The nanosystem promotes chemodynamic therapy (CDT), achieves radiosensitization, and activates the cGAS‐STING pathway.
Yinfei Zheng   +11 more
wiley   +1 more source

Symmetric dimethylarginine as a biomarker of renal impairment after a decade of follow-up. [PDF]

open access: yesSci Rep
Meyer H   +7 more
europepmc   +1 more source

Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine.

open access: yesSeminars in Nephrology, 2018
D. Moledina, C. Parikh
semanticscholar   +1 more source

Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease

open access: yesAdvanced Science, EarlyView.
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu   +15 more
wiley   +1 more source

Classifying AKI by Urine Output versus Serum Creatinine Level.

open access: yesJournal of the American Society of Nephrology, 2015
J. Kellum   +5 more
semanticscholar   +1 more source

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