Results 101 to 110 of about 2,449,132 (295)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
國小師資生國語發音錯誤之調查與分析 Investigation and Analysis of Mandarin Pronunciation Errors among Elementary Pre-service Teachers [PDF]
Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan教學中，教師的口齒清晰、表達流暢是相當重要的。臺灣的國小師培課程當中與國語發音最有關的應是「國音及說話」這一門課，此課程也是國語文教材法的先修課程，其重要性不言而喻。研究者連續多年在本校師培中心開設此課程，在教學過程中發現以下問題，首先是國小師資生國語發音與標準尚有段距離，其次是觀察到教材中的發音重點與師資生的發音錯誤或有出入，且難以具體評量國小師資生國語發音現況。為解決以上問題，本研究目的為調查國小師資生國語發音偏誤類型與比例，以此為基礎，提出「國音及說話」課程在國語發音上的教學建議 ...
張金蘭 Ching-Lan Chang
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Crossings, 2015 This article addresses representations of working-class life in Britain during the 1980s; specifically, experiences of recession, unemployment, and difficulty in the workplace.
Joseph Brooker
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Reading Magic: Deep Reading in the Creative writing Classroom
, 2023 This chapter explores a process-orientated approach to creative writing instruction that integrates writing and reading in the teaching of both traditional and contemporary fairy tales in the creative writing ...
Sulway, Nike, Cantrell, Kate
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Publishing in the "On Teaching" Category: Powerful Creative Writing. [PDF]
J Grad Med Educ, 2022 Gottlieb-Smith R +2 more
europepmc +1 more source
The problem of the exegesis in creative writing higher degrees [PDF]
, 2004 It has now become standard practice for there to be an exegetical component not only in creative writing PhDs, but also in Masters and even Honours dissertations.
Bourke, Nicole A., Neilsen, Philip M.
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