Results 291 to 300 of about 1,316,668 (360)

Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota

open access: yesAdvanced Science, EarlyView.
Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang   +15 more
wiley   +1 more source

Beyond Density: Unveiling the Trade‐Off in Catalytic Site Optimization Using Defect‐Engineered UiO‐66

open access: yesAdvanced Science, EarlyView.
A well‐designed experimental model reveals a trade‐off between intrinsic activity and catalytic site density in performance optimization, due to inherent diffusion resistance arising from substrate adsorption at catalytic sites. Abstract Enhancing intrinsic activity and increasing catalytic site density are two widely employed strategies to improve ...
Guo‐Ying Han   +13 more
wiley   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

open access: yesAdvanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato   +5 more
wiley   +1 more source

<i>Nurturing Creativity whilst Caring</i>: Participatory Action Research with family carers and a Recovery College. [PDF]

open access: yesFront Psychiatry
Bowness B   +9 more
europepmc   +1 more source

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