Results 171 to 180 of about 669 (248)

Redefining Debt-to-Health, a triple-win health financing instrument in global health. [PDF]

Global Health
Hu Y, Wang Z, Zhou S, Yang J, Chen Y, Wang Y, Xu M.   +6 more
europepmc   +1 more source

Engineering selective amyloid precursor protein inhibitors by machine learning and deep mutational scanning

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Deep mutational scanning (DMS) has proven effective for mapping protein–protein interactions (PPIs), but it cannot provide complete coverage of the mutation landscape, particularly for multi‐mutant variants. To address this limitation, we trained machine‐learning (ML) models on previously generated DMS data for a stabilized amyloid precursor ...
Reut Meiri, Oz Reuveni, Michal Levi, Evette S. Radisky, Niv Papo, Yaron Orenstein   +5 more
wiley   +1 more source

Functional studies on the cytochrome P450 splice variants CYP4F3A and CYP4F3B unveil the basis for their distinct physiological functions. [PDF]

Drug Metab Dispos
Alves Chagas BC, Brixius B, Pirhadi S, Mirtchev A, Ray S, Koes DR, Brixius-Anderko S.   +6 more
europepmc   +1 more source

Lunar Trailblazer Spacecraft Tracking and Mission Recovery Attempt: Characterization of Status and Behavior of a Non‐Cooperative Object in Cis‐Lunar Space

Earth and Space Science, Volume 13, Issue 8, August 2026.
Abstract Unexpectedly following launch, the Lunar Trailblazer mission experienced software anomalies that led it to orient solar panels away from the sun and lose communication with Earth. This paper describes efforts to determine the spacecraft state and attempt recovery of the mission's science at the Moon.
B. L. Ehlmann, J. Bellerose, G. Lantoine, E. Furlan, E. Scire, S. Fajardo‐Acosta, L. Bennett, M. Sanchez Net, T. J. W. Lazio, M. Brozović, J. Masiero, A. V. Steckel, P. A. Burke, M. Kimura, S. Foxman, M. P. M. Zaw, L. M. Lee, F. Clarke, M. Hauge, D. McDonald, J. Adler, R. Strauss, D. Trilling, C. S. Edwards, M. C. Nolan, D. Lyster, L. Robinson, A. T. Klesh, C. C. Seybold   +28 more
wiley   +1 more source

Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley   +1 more source

Does BRRD mitigate the bank-to-sovereign risk channel? [PDF]

PLoS One
Lamers M, Present T, Soenen N, Vennet RV.   +3 more
europepmc   +1 more source

Testing for Contagion in International Financial Markets: To See More, Go Higher

Financial Review, Volume 61, Issue 3, Page 725-763, August 2026.
ABSTRACT Traditional measures of financial contagion rely on correlation shifts, overlooking higher moments such as skewness and kurtosis. We examine contagion during two major financial crises, incorporating lower‐ and higher‐moment measures. We analyze stock market returns from 22 major markets at different frequencies, offering a global perspective ...
Simeon Coleman, Vitor Leone
wiley   +1 more source

Flexible Contract, Flexible Morale? Microcredit Design and Repayment Discipline

International Economic Review, Volume 67, Issue 3, Page 893-913, August 2026.
ABSTRACT Flexible repayment benefits borrowers, but practitioners fear increased moral hazard. Investigating their concerns requires disentangling repayment choices from repayment capacity, which is typically infeasible in field studies. We use a lab‐in‐the‐field experiment with 645 microcredit borrowers to cleanly identify the effect of repayment ...
Kristina Czura, Anett John, Lisa Spantig
wiley   +1 more source

FEDRANN: effective long-read overlap detection based on dimensionality reduction and approximate nearest neighbors. [PDF]

Gigascience
Zhang JY, Miao C, Qiu T, He J, Cao W, Lin W, Xia X, He L, Yang C, Sun Y, Zeng T, Li Y, Xu X, Ruan Y, Dong Y.   +14 more
europepmc   +1 more source